NDLI: Exploring Protein Architecture using 3D Shape-based Signatures

Content Provider	IEEE Xplore Digital Library
Author	Paquet, E. Viktor, H.L.
Copyright Year	2007
Description	Author affiliation: Nat. Res. Council of Canada, Ottawa (Paquet, E.)
Abstract	Consider the scenario where, for a prescription drug designed to treat a terminal illness, a particular protein has been successfully identified as a crucial, beneficial component in the drug compound. However, this protein has contra-indications and causes severe adverse effects in a certain subset of the population. If another protein from the same family, with similar structure and functionality, but without these adverse effects, can be found, the subsequent modification of the harmful drug has obvious benefits. This paper describes a new indexing and similarity search system to retrieve such protein structure family members, based on their 3D shape. Our approach is translation, scale and rotation invariant, which eliminates the need for prior structure alignment. Our experimental evaluation against seven (7) diverse protein families indicate that our system accurately and precisely locate all members of a family. We further illustrate this by showing that our system precisely retrieves the Homo Sapiens Hemoglobin family members, against a database containing 26,000 protein structures.
Starting Page	1204
Ending Page	1208
File Size	803038
Page Count	5
File Format	PDF
ISBN	9781424407873
ISSN	1557170X
DOI	10.1109/IEMBS.2007.4352513
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2007-08-22
Publisher Place	France
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Proteins Indexing Shape Drugs Bioinformatics Information retrieval Genetic mutations Databases Prototypes Labeling
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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