NDLI: Discrimination of ischemia and normal sinus rhythm for cardiac signals using a modified k means clustering algorithm

Content Provider	IEEE Xplore Digital Library
Author	Shrivastav, M. Iaizzo, P.
Copyright Year	2007
Description	Author affiliation: Univ. of Minnesota, Minneapolis (Iaizzo, P.) \|\| Minneapolis, Minneapolis (Shrivastav, M.)
Abstract	Over 15 million American are affected by coronary heart disease, according to the American Heart Association. Approximately 8 million have suffered a myocardial infarction. The economic and social consequences of this disease are staggering. A plethora of experimental and established therapies exist for this disease, such as stem cell therapy, growth factor injection, engineered cell transfection, etc. The use of these techniques relies on targeted therapeutic delivery. This paper describes mathematical techniques to extract key features from acquired action potential signals from ischemic and normal regions of the same heart. Using a modified means clustering technique on paired data, the best features are evaluated in multidimensional space. The results indicate promising clustering and separation of ischemic and normal beats using frequency domain computations, morphology analyses, and isoelectric point evaluations. Features were tested with data collected from a swine model of localized ischemia implanted with transmural electrodes and evaluated with a cross-validation approach. This research may have clinical significance to aid in the efficacious diagnosis or treatment of myocardial ischemia.
Starting Page	3856
Ending Page	3859
File Size	473310
Page Count	4
File Format	PDF
ISBN	9781424407873
ISSN	1557170X
DOI	10.1109/IEMBS.2007.4353174
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2007-08-22
Publisher Place	France
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Ischemic pain Rhythm Clustering algorithms Cardiac disease Heart Myocardium Cardiovascular diseases Medical treatment Stem cells Data mining
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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