NDLI: Screening for the Effects of Antiepileptic Drugs on Short Term Plasticity Using A Time Efficient Bioassay

Content Provider	IEEE Xplore Digital Library
Author	Gholmieh, G. Chen, L.S. Courellis, S.
Copyright Year	2007
Description	Author affiliation: Children Hosp. Los Angeles (CHLA), Los Angeles (Gholmieh, G.; Chen, L.S.) \|\| Univ. of Southern California, Los Angeles (Courellis, S.)
Abstract	Screening for changes in the short-term plasticity (STP) characteristics induced by antiepileptic drugs (AEDs) can be accelerated using a novel in vitro bioassay. The bioassay is based on the analysis of varying population spike (PS) amplitudes recorded in the CA1 region of the hippocampal slice in response to Poisson distributed random electrical stimuli. Three antiepileptic drugs (phenytoin 100 muM, carbamazepine 100 muM, and valproate 700 muM) were tested at maximal effective therapeutic concentrations. The data were analyzed using an advanced nonlinear approach that is more specific and time-efficient than the conventional paired pulse and fixed frequency train methods. STP was quantified by the first and the second order Volterra kernels. The first order kernel $(k_{2})$ represented the mean PS amplitude while the second order kernel $(k_{2})$ quantified the effect on the current PS amplitude of the interaction between the current stimulus impulse and each past stimulus impulse within a time (memory) window mu. The mean PS $(k_{2})$ decreased by 15%, 10%, and 7% when phenytoin, carbamazepine, and valproate were added respectively. Phenytoin caused an increase in the $k_{2}$ peak facilitation in the high frequency domain. Carbamazepine impaired frequency facilitation in the theta frequency range by causing a left shift in the second order kernel.
Starting Page	2247
Ending Page	2252
File Size	327488
Page Count	6
File Format	PDF
ISBN	9781424407873
ISSN	1557170X
DOI	10.1109/IEMBS.2007.4352772
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2007-08-22
Publisher Place	France
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Drugs Kernel Testing In vitro Data analysis Data acquisition Acceleration Frequency domain analysis Protocols State estimation
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Improving Bioassay Sensitivity for Neurotoxins Detection Using Volterra Based Third Order Nonlinear Analysis

A Gaussian Mixture Model for Time-Frequency Analysis of Atrial Fibrillation Electrocardiograms

Partial directed coherence statistical performance characteristics in frequency domain

Combined frequency and time domain sleep feature calculation

Separate estimation of long- and short-term systolic blood pressure variability from photoplethysmograph

Wearable Accelerometer System for Measuring the Temporal Parameters of Gait

Generalized volterra kernel model identification of spike-timing-dependent plasticity from simulated spiking activity

Accurate walking and running speed estimation using wrist inertial data

Pulse rate estimation using hydraulic bed sensor

Screening for the Effects of Antiepileptic Drugs on Short Term Plasticity Using A Time Efficient Bioassay

Similar Documents

Improving Bioassay Sensitivity for Neurotoxins Detection Using Volterra Based Third Order Nonlinear Analysis

A Gaussian Mixture Model for Time-Frequency Analysis of Atrial Fibrillation Electrocardiograms

Partial directed coherence statistical performance characteristics in frequency domain

Combined frequency and time domain sleep feature calculation

Separate estimation of long- and short-term systolic blood pressure variability from photoplethysmograph

Wearable Accelerometer System for Measuring the Temporal Parameters of Gait

Generalized volterra kernel model identification of spike-timing-dependent plasticity from simulated spiking activity

Accurate walking and running speed estimation using wrist inertial data

Pulse rate estimation using hydraulic bed sensor

Screening for the Effects of Antiepileptic Drugs on Short Term Plasticity Using A Time Efficient Bioassay