| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Clark, Abbot F. Millar, J. Cameron Pang, Iok-Hou Phan, Tien N. |
| Description |
Country affiliation: United States Author Affiliation: Millar JC ( North Texas Eye Research Institute (NTERI), University of North Texas Health Science Center, Fort Worth, Texas, United States 2Department of Cell Biology & Immunology, University of North Texas Health Science Center, Fort Worth, Texas, United States.); Phan TN ( North Texas Eye Research Institute (NTERI), University of North Texas Health Science Center, Fort Worth, Texas, United States 2Department of Cell Biology & Immunology, University of North Texas Health Science Center, Fort Worth, Texas, United States.); Pang IH ( North Texas Eye Research Institute (NTERI), University of North Texas Health Science Center, Fort Worth, Texas, United States 2Department of Cell Biology & Immunology, University of North Texas Health Science Center, Fort Worth, Texas, United States 3Depa.); Clark AF ( North Texas Eye Research Institute (NTERI), University of North Texas Health Science Center, Fort Worth, Texas, United States 2Department of Cell Biology & Immunology, University of North Texas Health Science Center, Fort Worth, Texas, United States.) |
| Abstract |
PURPOSE: We evaluated differences in aqueous humor dynamics (AHD) among several mouse strains within younger and older age groups. METHODS: Albino (A/J, BALB/cJ) and pigmented (C3H/HeJ, C57-BL/6J) mice (young [2½-4½ months] and aged [10-12 months]) were studied. Intraocular pressure (IOP) was measured. In cannulated eyes, episcleral venous pressure (Pe) was assessed (blood reflux). Other AHD parameters (outflow facility [C], aqueous humor formation rate [Fin]) were assessed (constant flow infusion). Uveoscleral outflow rate (Fu) was obtained by calculation (Fu(calc)) using the modified Goldmann equation, and in additional eyes (for comparison), by FITC-dextran perfusion (Fu(FITC-dex)). RESULTS: Intraocular pressure was higher in pigmented strains, but did not exhibit age-dependence, except in the C57-BL/6J strain. Fu(calc) decreased with age in BALB/cJ (↓83.3%), C3H/HeJ (↓78.0%), and C57-BL/6J (↓85.0%) strains. In the A/J strain, Fu(calc) decreased with age (↓70.0%), but not significantly. Fin decreased with age in the C3H/HeJ (↓53.6%) strain. In C57-BL/6J and A/J strains, Fin decreased with age, but not significantly. C in the BALB/cJ strain increased with age (↑62.5%). In C3H/HeJ and C57-BL/6J strains, C increased with age, but not significantly. Episcleral venous pressure ranged from 6.0 to 6.6 mm Hg (albino strains) to 8.5 to 8.9 mm Hg (pigmented strains). Pe was not age dependent, but was higher in pigmented animals. CONCLUSIONS: In mouse, Fu and Fin diminish with age. C tends to increase as animals progress to middle life. There are strain differences in Fu, IOP, C, Fin, and Pe. The current findings provide an important foundation for comparisons among different strains in different study reports. |
| ISSN |
01460404 |
| e-ISSN |
15525783 |
| Journal |
Investigative Opthalmology & Visual Science |
| Issue Number |
10 |
| Volume Number |
56 |
| Language |
English |
| Publisher |
Association for Research in Vision and Ophthalmology |
| Publisher Date |
2015-09-01 |
| Publisher Place |
United States |
| Access Restriction |
Open |
| Subject Keyword |
Aging Physiology Aqueous Humor Animals Intraocular Pressure Mice Mice, Inbred A Mice, Inbred Balb C Mice, Inbred C3h Mice, Inbred Strains Species Specificity Tonometry, Ocular Venous Pressure Research Support, Non-u.s. Gov't Discipline Ophthalmology |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Ophthalmology Sensory Systems Cellular and Molecular Neuroscience |
