NDLI: Light Exposure and Eye Growth in Childhood.

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Compartmental Innervation of the Superior Oblique Muscle in Mammals

Erp29 Attenuates Cigarette Smoke Extract-Induced Endoplasmic Reticulum Stress and Mitigates Tight Junction Damage in Retinal Pigment Epithelial Cells.

Functional Impact of Collagens on the Activity Directed by the Promoter of the 5 Integrin Subunit Gene in Corneal Epithelial Cells.

The Usefulness of Gaze Tracking as an Index of Visual Field Reliability in Glaucoma Patients.

Evaluation of the Association Between Common Genetic Variants Near the ABCA1 Gene and Primary Angle Closure Glaucoma in a Han Chinese Population.

Evolutionary Characterization of the Retinitis Pigmentosa GTPase Regulator Gene.

Effects of Cytokine Activation and Oxidative Stress on the Function of the Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells.

Assessment of Visual and Chromatic Functions in a Rodent Model of Retinal Degeneration.

Combined 60° Wide-Field Choroidal Thickness Maps and High-Definition En Face Vasculature Visualization Using Swept-Source Megahertz OCT at 1050 nm.

Systemic Retinaldehyde Treatment Corrects Retinal Oxidative Stress, Rod Dysfunction, and Impaired Visual Performance in Diabetic Mice.

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Residual and Dynamic Range of Retinal Nerve Fiber Layer Thickness in Glaucoma: Comparison of Three OCT Platforms.

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Blue Multifocal Pupillographic Objective Perimetry in Glaucoma.

Effects of Inflammasome Activation on Secretion of Inflammatory Cytokines and Vascular Endothelial Growth Factor by Retinal Pigment Epithelial Cells.

Regional Changes in Choroidal Thickness Associated With Accommodation.

Motion Information via the Nonfixating Eye Can Drive Optokinetic Nystagmus in Strabismus.

Differential Gene Expression Profiling of Orbital Adipose Tissue in Thyroid Orbitopathy.

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Inhibition of Noninfectious Uveitis Using Intravenous Administration of Collagen II-Specific Type 1 Regulatory T Cells.

The Effect of Age on the Temporal Summation of Achromatic Perimetric Stimuli.

Spatiotemporal Summation of Perimetric Stimuli in Early Glaucoma.

Impact of Corneal Endothelial Dysfunctions on Intraocular Oxygen Levels in Human Eyes.

Effects of Long-Wavelength Lighting on Refractive Development in Infant Rhesus Monkeys.

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Angiogenic and Inflammatory Vitreous Biomarkers Associated With Increasing Levels of Retinal Ischemia.

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Author Response: Comparison of Risk Factor Profiles for Primary Open-Angle Glaucoma Subtypes Defined by Pattern of Visual Field Loss: True Risk Factors or Arbituary Definition?

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Choroidal Thickness Evaluation Before and After Hemodialysis in Patients With and Without Diabetes.

Orbital Fibroblasts From Graves' Orbitopathy Patients Share Functional and Immunophenotypic Properties With Mesenchymal Stem/Stromal Cells.

Intraocular Pressure-Lowering Activity of NCX 470, a Novel Nitric Oxide-Donating Bimatoprost in Preclinical Models.

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Establishing Corneal Cross-Linking With Riboflavin and UV-A in the Mouse Cornea In Vivo: Biomechanical Analysis.

Application of Graphene as Candidate Biomaterial for Synthetic Keratoprosthesis Skirt.

Contralateral Clinically Unaffected Eyes of Patients With Unilateral Infectious Keratitis Demonstrate a Sympathetic Immune Response.

Corneal Nerve Damage In Microbial Keratitis.

Prediction of Retinal Ischemia in Branch Retinal Vein Occlusion: Spectral-Domain Optical Coherence Tomography Study.

Glaucoma and the Role of Cerebrospinal Fluid Dynamics:To the Editor

Glaucoma and the Role of Cerebrospinal Fluid Dynamics:Response

Inner Retinal Oxygen Extraction Fraction in Response to Light Flicker Stimulation in Humans

Effects of Tauroursodeoxycholic Acid and Alpha-Lipoic-Acid on the Visual Response Properties of Cat Retinal Ganglion Cells: An In Vitro Study.

Docosahexaenoic Acid Slows Visual Field Progression in X-Linked Retinitis Pigmentosa: Ancillary Outcomes of the DHAX Trial.

Arsenic Trioxide Inhibits Proliferation of Rabbit Tenon's Capsule Fibroblasts After Trabeculectomy by Downregulating Expression of Extracellular Matrix Proteins.

A Founder Mutation in MYO7A Underlies a Significant Proportion of Usher Syndrome in Indigenous South Africans: Implications for the African Diaspora.

Doxycycline Attenuates Endotoxin-Induced Uveitis by Prostaglandin E2-EP4 Signaling.

Intraocular Pharmacokinetics of Povidone-Iodine and Its Effects on Experimental Staphylococcus epidermidis Endophthalmitis.

A Novel ImageJ Macro for Automated Cell Death Quantitation in the Retina.

Hypoxia-Inducible Factor-1 Is Associated With Sprouting Angiogenesis in the Murine Laser-Induced Choroidal Neovascularization Model.

Outcome Preferences in Patients With Noninfectious Uveitis: Results of a Best-Worst Scaling Study.

Rare Variants in the Functional Domains of Complement Factor H Are Associated With Age-Related Macular Degeneration.

Structural Measurements for Monitoring Change in Glaucoma: Comparing Retinal Nerve Fiber Layer Thickness With Minimum Rim Width and Area.

Relationship Between Nocturnal Intraocular Pressure Variations and Sleep Macrostructure.

Melanopsin-Mediated Post-Illumination Pupil Response in Early Age-Related Macular Degeneration.

Implications of Optic Disc Tilt in the Progression of Primary Open-Angle Glaucoma.

Impact of Wet Macular Degeneration on the Execution of Natural Actions.

Efficacy of VIP as Treatment for Bacteria-Induced Keratitis Against Multiple Pseudomonas aeruginosa Strains.

Quantitative Analysis of Corneal Energy Dissipation and Corneal and Orbital Deformation in Response to an Air-Pulse in Healthy Eyes.

IGF-1 Regulates the Extracellular Level of Active MMP-2 and Promotes Müller Glial Cell Motility.

In Vivo Visualization of Endoplasmic Reticulum Stress in the Retina Using the ERAI Reporter Mouse.

Pathological Effects of Mutant C1QTNF5 (S163R) Expression in Murine Retinal Pigment Epithelium.

Denervation of the Lacrimal Gland Leads to Corneal Hypoalgesia in a Novel Rat Model of Aqueous Dry Eye Disease.

Erratum. M2 Macrophages Enhance Pathological Neovascularization in the Mouse Model of Oxygen-Induced Retinopathy.

Evaluation of Fluorophotometry to Assess the Vitreal Pharmacokinetics of Protein Therapeutics.

Effect of Age and Glaucoma on the Detection of Darks and Lights.

Protective Effects of Antiplacental Growth Factor Antibody Against Light-Induced Retinal Damage in Mice.

Cone-Photoreceptor Density in Adolescents With Type 1 Diabetes.

Blink Rate and Incomplete Blinks in Six Different Controlled Hard-Copy and Electronic Reading Conditions.

Lack of Association Between Corneal Hysteresis and Corneal Resistance Factor With Glaucoma Severity in Primary Angle Closure Glaucoma.

Relationship of Virulence Factors and Clinical Features in Keratitis Caused by Pseudomonas aeruginosa.

The Ability of SD-OCT to Differentiate Early Glaucoma With High Myopia From Highly Myopic Controls and Nonhighly Myopic Controls.

Time-Resolved Ultra-High Resolution Optical Coherence Tomography for Real-Time Monitoring of Selective Retina Therapy.

Enriched Cultures of Retinal Cells From BJNhem20 Human Embryonic Stem Cell Line of Indian Origin.

Differentiation of Diabetic Macular Edema From Pseudophakic Cystoid Macular Edema by Spectral-Domain Optical Coherence Tomography.

Visualization of Nerve Fiber Orientations in the Human Optic Chiasm Using Photomicrographic Image Analysis.

Two-Photon Fluorescence Microscopy for Determination of the Riboflavin Concentration in the Anterior Corneal Stroma When Using the Dresden Protocol.

Expression Profiling of Human Schlemm's Canal Endothelial Cells From Eyes With and Without Glaucoma.

NADPH Oxidase-Mediated ROS Production Determines Insulin's Action on the Retinal Microvasculature.

Number of People Blind or Visually Impaired by Cataract Worldwide and in World Regions, 1990 to 2010.

Infiltration of Plasma Cells in the Iris of Children With ANA-Positive Anterior Uveitis.

Light Exposure and Eye Growth in Childhood.

A Diagnostic Calculator for Detecting Glaucoma on the Basis of Retinal Nerve Fiber Layer, Optic Disc, and Retinal Ganglion Cell Analysis by Optical Coherence Tomography.

Retinal Blood Flow and Retinal Blood Oxygen Saturation in Mild to Moderate Diabetic Retinopathy.

Inferring an Evolutionary Tree of Uveal Melanoma From Genomic Copy Number Aberrations.

Intravitreal Ciliary Neurotrophic Factor Transiently Improves Cone-Mediated Function in a CNGB3-/- Mouse Model of Achromatopsia.

Strain-Dependent Anterior Segment Dysgenesis and Progression to Glaucoma in Col4a1 Mutant Mice

Neuroprotective Effects of Voluntary Exercise in an Inherited Retinal Degeneration Mouse Model.

Predicting Lens Diameter: Ocular Biometry With High-Resolution MRI.

CYP2E1 in the Human Retinal Pigment Epithelium: Expression, Activity, and Induction by Ethanol.

Sufficient Evidence for Lymphatics in the Developing and Adult Human Choroid?

Author Response: Sufficient Evidence for Lymphatics in the Developing and Adult Human Choroid?

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Light Exposure and Eye Growth in Childhood.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Collins, Michael J. Vincent, Stephen J. Read, Scott A.
Abstract	PURPOSE: The purpose of this study was to examine the relationship between objectively measured ambient light exposure and longitudinal changes in axial eye growth in childhood. METHODS: A total of 101 children (41 myopes and 60 nonmyopes), 10 to 15 years of age participated in this prospective longitudinal observational study. Axial eye growth was determined from measurements of ocular optical biometry collected at four study visits over an 18-month period. Each child's mean daily light exposure was derived from two periods (each 14 days long) of objective light exposure measurements from a wrist-worn light sensor. RESULTS: Over the 18-month study period, a modest but statistically significant association between greater average daily light exposure and slower axial eye growth was observed (P = 0.047). Other significant predictors of axial eye growth in this population included children's refractive error group (P < 0.001), sex (P < 0.01), and age (P < 0.001). Categorized according to their objectively measured average daily light exposure and adjusting for potential confounders (age, sex, baseline axial length, parental myopia, nearwork, and physical activity), children experiencing low average daily light exposure (mean daily light exposure: 459 ± 117 lux, annual eye growth: 0.13 mm/y) exhibited significantly greater eye growth than children experiencing moderate (842 ± 109 lux, 0.060 mm/y), and high (1455 ± 317 lux, 0.065 mm/y) average daily light exposure levels (P = 0.01). CONCLUSIONS: In this population of children, greater daily light exposure was associated with less axial eye growth over an 18-month period. These findings support the role of light exposure in the documented association between time spent outdoors and childhood myopia.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	11
Volume Number	56
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2015-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Emmetropia Physiology Eye Myopia Physiopathology Adolescent Axial Length, Eye Radiation Effects Biometry Growth & Development Longitudinal Studies Prospective Studies Refraction, Ocular Observational Study Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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