NDLI: Age-associated changes in the retinal nerve fiber layer and optic nerve head.

Please wait, while we are loading the content...

Year: 2017 Volume: 58

Year: 2016 Volume: 57

Year: 2015 Volume: 56

Year: 2014 Volume: 56

Year: 2014 Volume: 55

Year: 2014 Volume: 55 Issue: 12

Year: 2014 Volume: 55 Issue: 11

Year: 2014 Volume: 55 Issue: 10

Year: 2014 Volume: 55 Issue: 9

Year: 2014 Volume: 55 Issue: 8

Monomethylfumarate induces Î³-globin expression and fetal hemoglobin production in cultured human retinal pigment epithelial (RPE) and erythroid cells, and in intact retina.

Associations between abnormal rod-mediated dark adaptation and health and functioning in older adults with normal macular health.

British Ocular Syphilis Study (BOSS): 2-year national surveillance study of intraocular inflammation secondary to ocular syphilis.

Impact of cataract surgery on sleep in patients receiving either ultraviolet-blocking or blue-filtering intraocular lens implants.

The effect of aging on crowded letter recognition in the peripheral visual field.

Antagonizing c-Cbl Enhances EGFR-Dependent Corneal Epithelial Homeostasis

Molecular changes and vision loss in a mouse model of closed-globe blast trauma.

Tamoxifen toxicity in cultured retinal pigment epithelial cells is mediated by concurrent regulated cell death mechanisms.

Isolation and characterization of mesenchymal progenitor cells from human orbital adipose tissue.

Androgen deficiency and dry eye syndrome in the aging male.

Gene Therapy With Mitochondrial Heat Shock Protein 70 Suppresses Visual Loss and Optic Atrophy in Experimental Autoimmune Encephalomyelitis

Notch signaling functions in retinal pericyte survival.

Corneal wound healing, a newly identified function of CAP37, is mediated by protein kinase C delta (PKCÎ´).

Ultrastructural changes associated with dexamethasone-induced ocular hypertension in mice.

Photic injury to cultured RPE varies among individual cells in proportion to their endogenous lipofuscin content as modulated by their melanosome content.

Bis(zinc-dipicolylamine), Zn-DPA, a new marker for apoptosis.

Topical administration of lacritin is a novel therapy for aqueous-deficient dry eye disease.

Quantitative autofluorescence and cell density maps of the human retinal pigment epithelium.

Reading ability and reading engagement in older adults with glaucoma.

Choroid, Haller's, and Sattler's layer thickness in intermediate age-related macular degeneration with and without fellow neovascular eyes.

Age-associated changes in the retinal nerve fiber layer and optic nerve head.

Elevated transforming growth factor ß1 in plasma of primary open-angle glaucoma patients.

Visual acuity and increased mortality: the role of allostatic load and functional status.

Effect of vitamin D receptor knockout on cornea epithelium wound healing and tight junctions.

Characteristics of fixational eye movements in people with macular disease.

TULP1 mutations causing early-onset retinal degeneration: preserved but insensitive macular cones.

The Zeb proteins Î´EF1 and Sip1 may have distinct functions in lens cells following cataract surgery.

Nystagmus and related fixation instabilities following extraction of unilateral infantile cataract in the Infant Aphakia Treatment Study (IATS).

Pharmacologically stimulated pupil and accommodative changes in Guinea pigs.

Accommodation in astigmatic children during visual task performance.

A useful mouse model of glucocorticoid-induced ocular hypertension.

Year: 2014 Volume: 55 Issue: 7

Year: 2014 Volume: 55 Issue: 6

Year: 2014 Volume: 55 Issue: 5

Year: 2014 Volume: 55 Issue: 4

Year: 2014 Volume: 55 Issue: 3

Year: 2014 Volume: 55 Issue: 2

Year: 2014 Volume: 55 Issue: 1

Year: 2013 Volume: 54

Year: 2012 Volume: 53

Year: 2011 Volume: 52

Year: 2010 Volume: 51

Year: 2009 Volume: 50

Year: 2008 Volume: 49

Age-associated changes in the retinal nerve fiber layer and optic nerve head.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Evans, Kelsey B. Harwerth, Ronald S. Patel, Nimesh B. Lim, Mimi Gajjar, Avni
Description	Country affiliation: United States Author Affiliation: Patel NB ( University of Houston College of Optometry, Department of Vision Sciences, Houston, Texas, United States.); Lim M ( State University of New York College of Optometry, New York, New York, United States.); Gajjar A ( University of Houston College of Optometry, Department of Vision Sciences, Houston, Texas, United States.); Evans KB ( University of Houston College of Optometry, Department of Vision Sciences, Houston, Texas, United States.); Harwerth RS ( University of Houston College of Optometry, Department of Vision Sciences, Houston, Texas, United States.)
Abstract	PURPOSE: Optical coherence tomography (OCT) measures of the retinal nerve fiber layer (RNFL) thickness and neuroretinal rim (NRR) parameters are often used as a surrogate for retinal ganglion cell content. The purpose of this study was to investigate the relationship between these morphological measures and the aging effects on these structures. METHODS: One hundred thirteen healthy individuals, aged 19 to 76 years, with no prior history of retinal of optic nerve head pathology were recruited. A circumpapillary and radial OCT scan centered on the optic nerve head (ONH) was used for data analysis. Transverse scaling was calculated for each subject using measures from optical biometry. Custom algorithms were used for morphological analysis of the ONH NRR and RNFL that included quantification of major retinal vascular contribution. RESULTS: There was a significant age-related loss of RNFL thickness (-0.23 µm/y, R(2) = 0.24, P < 0.01), major retinal vascular contribution (-0.03 µm/y, R(2) = 0.07, P = 0.01, neural rim volume (NRV, -0.004 mm(3)/y, R(2) = 0.15, P < 0.01), and minimum rim width (MRW, -1.77 µm/y, R(2) = 0.23, P < 0.01) before, and after, incorporating the Bruch's membrane opening size (sMRW, -1.86 µm/y, R(2) = 0.22, P < 0.01). When normalized, the rates of change for ONH NRR parameters (NRV, 0.69%/y and sMRW, 0.50%/y) exceeded that of RNFL thickness (0.19%/y, P < 0.01). CONCLUSIONS: Although both RNFL and ONH NRR parameters contain axons of retinal ganglion cells, there are differences in age-related changes in these measures that should be considered in clinical application.
ISSN	01460404
e-ISSN	15525783
DOI	10.1167/iovs.14-14303
Journal	Investigative Opthalmology & Visual Science
Issue Number	8
Volume Number	55
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2014-07-22
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Aging Optic Disk Anatomy & Histology Retinal Ganglion Cells Cytology Axons Biometry Tomography, Optical Coherence Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in