NDLI: Predictors of normal optic nerve head, retinal nerve fiber layer, and macular parameters measured by spectral domain optical coherence tomography.

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Predictors of normal optic nerve head, retinal nerve fiber layer, and macular parameters measured by spectral domain optical coherence tomography.

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Predictors of normal optic nerve head, retinal nerve fiber layer, and macular parameters measured by spectral domain optical coherence tomography.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kumar, Anjul Garudadri, Chandra S. Babu, Jonnadula G. Rao, Harsha L. Senthil, Sirisha Kumar, Addepalli U.
Description	Country affiliation: India Author Affiliation: Rao HL ( VST Glaucoma Center, L. V. Prasad Eye Institute, Banjara Hills, Hyderabad, 500034, India. harshabl.76@gmail.com)
Abstract	PURPOSE: To evaluate the effects of signal strength, age, sex, optic disc size, and axial length on the normal optic nerve head (ONH), retinal nerve fiber layer (RNFL), and macular measurements with spectral domain optical coherence tomography (SD-OCT). METHODS: In an observational, cross-sectional study, 119 eyes of 60 normal subjects of Indian origin underwent ONH, RNFL, and macular imaging with SD-OCT during the same visit. Linear mixed-modeling methods were used to evaluate the effects of signal strength, age, sex, optic disc area, and axial length on ONH, RNFL, and macular measurements. RESULTS: ONH rim measurements increased and cup measurements decreased with increasing signal strengths. For a 10-unit increase in signal strength, total rim area increased by a mean of 0.1 mm(2). ONH measurements also increased with increasing optic disc size. Rim measurements decreased and cup measurements increased with increasing axial length. None of the predictors influenced RNFL measurements. Macular inner retinal thickness decreased by a mean of 1.7 µm and macular full retinal thickness decreased by an average of 3.4 µm for every decade's increase in age. Sex did not influence any of the measurements. CONCLUSIONS: Signal strength, optic disc size, and axial length had a significant effect on ONH measurements, whereas age had a significant effect on macular measurements. None of the predictors evaluated influenced the RNFL measurements. These predictors should be considered when evaluating change in the structural measurements in glaucoma over time.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	2
Volume Number	52
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2011-02-25
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Macula Lutea Anatomy & Histology Nerve Fibers Optic Disk Retinal Ganglion Cells Cytology Tomography, Optical Coherence Cross-sectional Studies Reference Values Sex Factors Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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