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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Oubraham, Hassiba Cohen, Salomon Y. Samimi, Sepideh Marotte, David Bouzaher, Ines Bonicel, Pierre Fajnkuchen, Franck Tadayoni, Ramin |
| Description | Country affiliation: France Author Affiliation: Oubraham H ( Departement of Ophthalmology, Centre Hospitalier, Orleans, France.) |
| Abstract | PURPOSE: The purpose of this study was to compare two strategies for retreatment with ranibizumab in exudative age-related macular degeneration. METHOD: Two series of consecutive patients treated with ranibizumab in a hospital-based department of ophthalmology were analyzed retrospectively: the first series (n = 52), after as-needed reinjections (PRN group) and the second (n = 38) after reinjections according to the Inject and Extend dosing method (IaE group). Patients' baseline characteristics, type of choroidal neovascularization, and Early Treatment Diabetic Retinopathy Study initial and final visual acuity (at 52 ± 4 weeks) were recorded in each group. Groups were compared by the Mann-Whitney U test or Fisher's exact test. RESULTS: Groups were well balanced at baseline for age (P = 0.58), sex (P = 0.66), laterality (P > 0.99), and initial visual acuity (P = 0.33). At 1 year, the mean gain in visual acuity was greater in the IaE group than in the PRN group (+10.8 ± 8.8 vs. +2.3 ± 17.4 letters, P = 0.036), but eyes in the IaE group were given significantly more injections (7.8 ± 1.3 vs. 5.2 ± 1.9 injections, P < 0.001). The number of follow-up visits attended was similar (8.5 ± 1.1 vs. 8.8 ± 1.5, P = 0.2085). CONCLUSION: Patients reinjected by the IaE dosing method had a far better visual outcome but after more injections. |
| File Format | HTM / HTML |
| ISSN | 0275004X |
| Issue Number | 1 |
| Volume Number | 31 |
| e-ISSN | 15392864 |
| Journal | Retina |
| Language | English |
| Publisher | Lippincott Williams & Wilkins |
| Publisher Date | 2011-01-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Ophthalmology Angiogenesis Inhibitors Administration & Dosage Antibodies, Monoclonal Choroidal Neovascularization Drug Therapy Exudates And Transudates Metabolism Macular Degeneration Complications Aged Aged, 80 And Over Antibodies, Monoclonal, Humanized Etiology Physiopathology Dose-response Relationship, Drug Female Humans Injections, Intraocular Male Middle Aged Ranibizumab Retreatment Retrospective Studies Visual Acuity Vitreous Body Comparative Study Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Ophthalmology |
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