NDLI: Correlations between frailty index and inflammatory markers derived from blood cell count in the United States

Content Provider	Springer Nature : BioMed Central
Author	Han, Shaojie Zhang, Zenghui Cheng, Siyuan Han, Yuchen Wang, Qianyun Xi, Yangbo Li, Panpan Li, Fengjuan Guo, Jun
Abstract	Background Complete blood cell count (CBC)-derived inflammatory biomarkers are crucial indicators of adverse outcomes and possess predictive value for a wide range of diseases. The objective of this study was to evaluate the links between CBC-derived inflammatory biomarkers and frailty index. Methods Information was gathered from the National Health and Nutrition Examination Survey (NHANES) spanning the years 1999 to 2016. The research investigated the correlation between inflammatory biomarkers derived from CBC, including the neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), systemic inflammatory response index (SIRI), and systemic immune-inflammation index (SII), and Rockwood’s frailty index, using logistic regression analyses. Results In total, the cross-sectional study involved 13,507 U.S. adults aged 50 and older, with 3,729 individuals (24%) meeting the criteria for frailty. After adjusting for confounding factors, elevated levels of logNLR (odds ratio [OR] 3.45, 95% confidence interval [CI] 2.52–4.73), logMLR (OR 3.58, 95% CI 2.44–5.25), logSIRI (OR 2.77, 95% CI 2.17–3.55), and logSII (OR 1.89, 95% CI 1.44–2.48) were significantly associated with an increased frailty index in the entire study population. We also found that frailty index and inflammatory biomarkers derived from CBC have a non-linear relationship by restricted cubic spline. Conclusions Our findings indicate a correlation between frailty index and NLR, MLR, SIRI, and SII among elderly adults. Considering their wide accessibility in both clinical and laboratory practice, these biomarkers may be recommended as potential indicators for the development of frailty.
Related Links	https://bmcpublichealth.biomedcentral.com/counter/pdf/10.1186/s12889-024-20908-9.pdf
Ending Page	11
Page Count	11
Starting Page	1
File Format	HTM / HTML
ISSN	14712458
DOI	10.1186/s12889-024-20908-9
Journal	BMC Public Health
Issue Number	1
Volume Number	24
Language	English
Publisher	BioMed Central
Publisher Date	2024-12-18
Access Restriction	Open
Subject Keyword	Public Health Medicine Epidemiology Biostatistics Vaccine Environmental Health Inflammation biomarkers Frailty index NHANES Medicine/Public Health
Content Type	Text
Resource Type	Article
Subject	Public Health, Environmental and Occupational Health
Journal Impact Factor	3.5/2023
5-Year Journal Impact Factor	3.9/2023

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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