NDLI: The association between BMI and cognition in India: data from the Longitudinal Aging Study in India (LASI)

Content Provider	Springer Nature : BioMed Central
Author	Nichols, Emma Gross, Alden L. Hu, Peifeng Sekher, T. V. Dey, Aparajit B. Lee, Jinkook
Abstract	Background High body-mass index (BMI) is an established risk factor for late-life cognitive impairment and dementia, but most evidence comes from high-income contexts. Existing evidence from cross-sectional data in low- and middle-income settings is inconsistent, and many studies do not adequately address potential sources of bias. Methods We used data from Wave 1 of the Longitudinal Aging Study in India (LASI) (analytic N = 56,753) to estimate the association between BMI categories and cognitive functioning among older adults aged 45 + years using survey-weighted linear regression models stratified by gender and controlling for potential confounders including demographic factors, socio-economic status (SES) characteristics, and health-related behaviors. To probe potential sources of bias, including residual confounding and reverse causation, we used weighting and trimming methods, sample restriction, and explored effect modification. Results In fully adjusted models, relative to normal BMI underweight BMI was associated with lower cognitive scores (Men: -0.16 SD difference, 95% CI -0.18, -0.13; Women: -0.12 SD, -0.15, -0.10). Overweight and obesity were associated with higher cognitive scores in both men (overweight: 0.09; 0.07, 0.12, obese: 0.10; 0.05, 0.15) and women (overweight: 0.09; 0.07–0.12, obese: 0.12; 0.08–0.15). Estimates were similar after weighting and trimming but were attenuated after excluding those with low cognition (≥1 SD below the mean relative to those with similar demographic characteristics). Positive associations between overweight and obese BMI and cognition were attenuated or null in those living in urban settings and those with higher levels of educational attainment. Conclusions Underweight BMI is a risk factor for poor cognitive outcomes in adults 45 years and older and may be indicative of poor nutritional status and life-course disadvantage in India. In tandem with existing literature, supplemental analyses and effect modification results indicate that unmeasured confounding and reverse causation may explain the observed positive associations between overweight and obese BMI and cognitive functioning from cross-sectional studies in low- and middle-income settings. Future data with longitudinal follow-up will be helpful to further disentangle biases.
Related Links	https://bmcpublichealth.biomedcentral.com/counter/pdf/10.1186/s12889-024-20101-y.pdf
Ending Page	11
Page Count	11
Starting Page	1
File Format	HTM / HTML
ISSN	14712458
DOI	10.1186/s12889-024-20101-y
Journal	BMC Public Health
Issue Number	1
Volume Number	24
Language	English
Publisher	BioMed Central
Publisher Date	2024-10-05
Access Restriction	Open
Subject Keyword	Public Health Medicine Epidemiology Biostatistics Vaccine Environmental Health Cognition Body mass index Obesity India Medicine/Public Health
Content Type	Text
Resource Type	Article
Subject	Public Health, Environmental and Occupational Health
Journal Impact Factor	3.5/2023
5-Year Journal Impact Factor	3.9/2023

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Association between physical activity and longitudinal change in body mass index in middle-aged and older adults

Decomposing urban-rural differences in multimorbidity among older adults in India: a study based on LASI data

Association between the triglyceride glucose-body mass index and mortality risk in cardiovascular disease populations: a longitudinal cohort study

Relationship between BMI with percentage body fat and obesity in Singaporean adults – The Yishun Study

An assessment of anthropometric indices and its association with NCDs among the older adults of India: evidence from LASI Wave-1

Association of frailty with non-laboratory based cardiovascular disease risk score among older adults and elderly population: insights from longitudinal aging study in India (LASI-1st wave)

Depression and body mass index, a u-shaped association

Association between serum vitamin C and body mass index in adolescents aged 12–19 years

COVID-19, body mass index and cholesterol: an ecological study using global data

The association between BMI and cognition in India: data from the Longitudinal Aging Study in India (LASI)

Similar Documents

Association between physical activity and longitudinal change in body mass index in middle-aged and older adults

Decomposing urban-rural differences in multimorbidity among older adults in India: a study based on LASI data

Association between the triglyceride glucose-body mass index and mortality risk in cardiovascular disease populations: a longitudinal cohort study

Relationship between BMI with percentage body fat and obesity in Singaporean adults – The Yishun Study

An assessment of anthropometric indices and its association with NCDs among the older adults of India: evidence from LASI Wave-1

Association of frailty with non-laboratory based cardiovascular disease risk score among older adults and elderly population: insights from longitudinal aging study in India (LASI-1st wave)

Depression and body mass index, a u-shaped association

Association between serum vitamin C and body mass index in adolescents aged 12–19 years

COVID-19, body mass index and cholesterol: an ecological study using global data

The association between BMI and cognition in India: data from the Longitudinal Aging Study in India (LASI)