NDLI: The association between maternal smoking during pregnancy and multimorbidity of non-communicable chronic diseases trajectory in offspring

Content Provider	Springer Nature : BioMed Central
Author	Wang, Hang Sun, Xinyi Wang, Zheng Liu, Hui Huang, Jiaxin Tang, Yiwei Wang, Shanshan Qiao, Conghui Su, Mengqi Lei, Qianqian Wei, Wei Sun, Changhao Han, Tianshu Jiang, Wenbo
Abstract	Objectives Although a few studies have found that maternal smoke during pregnancy (MSDP) is linked to a range of non-communicable chronic diseases (NCDs) in offspring, its association with the onset, progression, and prognosis of multimorbidity of NCDs (MNCDs) has never been studied. Study design Population-based prospective cohort study. Method A total of 318,122 adults aged 18–87 years who were free of heart disease, stroke, and diabetes at baseline were selected. MNCDs was defined as the coexistence of two or three NCDs, including CVDs (coronary heart disease and stroke), cancer (digest, breast, lung, and urination), diabetes (type 1 and type 2), and CLRD (COPD and asthma). Then we used multi-state model to analyse the impacts of MSDP on the progression of MNCDs in the offspring. Associations between MSDP and transition trajectory were analyzed with results expressed as hazard ratio (HR) and 95% confidence interval (95% CI). Results During the 70.2 years of follow-up, a total of 112,894 participants developed first NCDs (FNCDs), among whom 28,195 developed MNCDs and 21,452 subsequently died. After adjustment for potential confounders, the MSDP was associated with the transition trajectory from baseline to FNCD (HR = 1.10, 95%CI:1.09–1.11) and from FNCDs to MNCDs (HR = 1.08,95%CI:1.06–1.10). Meanwhile, the MSDP was associated with the transition trajectory from MNCDs to death (HR = 1.07,95%CI:1.03–1.11). Further, these association became more pronounced among the offspring who smoke (HRbaseline→FNCDs=1.13, 95%CI:1.12–1.15; HRFNCD→MNCD=1.13, 95%CI:1.12–1.15; HRMNCDs→death=1.11, 95%CI:1.16–1.16); whereas among the offspring who do not smoke, only the transition trajectory from baseline to FNCDs was observed (HR = 1.07, 95%CI:1.05–1.09). Conclusion This study suggested that the MSDP is associated with almost all transition phases of MNCDs development and increases the mortality risk of MNCDs in offspring who smoke, and these transition trajectories can be largely reduced by smoking cessation among offspring.
Related Links	https://bmcpublichealth.biomedcentral.com/counter/pdf/10.1186/s12889-024-20686-4.pdf
Ending Page	13
Page Count	13
Starting Page	1
File Format	HTM / HTML
ISSN	14712458
DOI	10.1186/s12889-024-20686-4
Journal	BMC Public Health
Issue Number	1
Volume Number	24
Language	English
Publisher	BioMed Central
Publisher Date	2024-11-26
Access Restriction	Open
Subject Keyword	Public Health Medicine Epidemiology Biostatistics Vaccine Environmental Health Maternal smoking Pregnancy Multi-morbidity pattern UK biobank Medicine/Public Health
Content Type	Text
Resource Type	Article
Subject	Public Health, Environmental and Occupational Health
Journal Impact Factor	3.5/2023
5-Year Journal Impact Factor	3.9/2023

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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