NDLI: Effects of ultrasound parameters on the acoustic characteristics of phase-change droplets

Content Provider	IEEE Xplore Digital Library
Author	Wei-Pu Kao Shih-Tsung Kang Chih-Kuang Yeh
Copyright Year	2014
Description	Author affiliation: Dept. of Biomed. Eng. & Environ. Sci., Nat. Tsing Hua Univ., Hsinchu, Taiwan (Wei-Pu Kao; Shih-Tsung Kang; Chih-Kuang Yeh)
Abstract	Phase-change droplets (PCDs) can be vaporized into bubbles by ultrasound (acoustic droplet vaporization, ADV) as promising diagnostic and therapeutic agents. The substantial volume expansion during the droplet-to-bubble transition with duration of a few microseconds may produce low-frequency shock wave, serving as the acoustic characteristics for monitoring and control of ADV. In this study we investigated the influence of ultrasound parameters including acoustic frequency, pulse duration, and pressure upon producing low-frequency shock wave from ADV process. Moreover, optimization of shock wave dose for pulse sequences were evaluated and measured by the total volume of vaporized droplets with the ADV efficiency experiments. The infused droplets were exposed to 3.5- and 10-MHz high-intensity focused ultrasound (HIFU) Hanning window weighted pulses with pulse durations from 3 to 50 cycles at varying pressures from 4 to 12 MPa. A 0.5-MHz transducer (for shock wave dose estimation) and a 1-MHz (for quantitative analysis) were confocally-arranged with the HIFU transducers for passive acoustic detection of low frequency shock wave. Increasing the pulse duration and pressure, the shock wave dose enhance during the variation of varying pulse length from 3 to 15 cycle, then decreased from 15 to 50 cycle. However, the effect of pulse durations of ADV efficiency at 10 MPa was insignificant. By changing pulse duration, result confirmed that no significant but significant on ADV efficiency measurement and shock wave dose evaluation, respectively. In the future, the techniques of the optimization low frequency had the potential application for physical studies in the development of droplet-specific imaging for real-time monitoring of therapeutic process.
Starting Page	1790
Ending Page	1793
File Size	621835
Page Count	4
File Format	PDF
e-ISBN	9781479970490
DOI	10.1109/ULTSYM.2014.0444
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2014-09-03
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Shock waves Acoustics Ultrasonic imaging Transducers Time-frequency analysis Radio frequency Imaging low-frequency shock wave acoustic droplet vaporization phase-change droplet interial cavitation
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in