NDLI: Non-contact photoacoustic characterization of retinal vasculature for brain-injury assessment

Content Provider	IEEE Xplore Digital Library
Author	Sampathkumar, A. Silverman, R.H.
Copyright Year	2014
Description	Author affiliation: F.L. Lizzi Center for Biomed. Eng., Riverside Res., New York, NY, USA (Sampathkumar, A.) \|\| Dept. of Ophthalmology, Columbia Univ. Med. Center, New York, NY, USA (Silverman, R.H.)
Abstract	This paper describes use of a non-contact photoacoustic method to characterize blood vessels in the retina for brain injury assessment. Retinal hemorrhages (RHs) and vascular abnormalities can serve as diagnostic indicators of head trauma. Ensuring an accurate and complete diagnosis of the trauma requires a quantitative description of the hemorrhages. In this work, we describe an optical interferometry-based photoacoustic (PA) microscope (PAM) to remotely evaluate retinal tissue at sub-micron resolution with an ultra-broadband detection bandwidth (1 GHz). To demonstrate feasibility, ex-vivo porcine retina specimens containing typical blood-vessel networks were imaged using our all-optical PAM. PA signals were generated in the tissue by a 532-nm pulsed laser, and PA-induced broadband ultrasound signals were detected at the surface of the specimen using an optical interferometer operating at 532 nm. K-space reconstruction methods were employed to obtain the tissue properties by time-reversing and back-propagating the measured signals into the medium. A tunable pulsed laser was employed to perform multispectral PA imaging of the vasculature to demonstrate feasibility of measuring blood volume, oxygen concentration and lipids. Multispectral PA data were obtained to a depth of 5 mm, in raster-scanned steps of 50 microns over the wavelength range of 680 to 950 nm.
Starting Page	843
Ending Page	845
File Size	1340971
Page Count	3
File Format	PDF
e-ISBN	9781479970490
DOI	10.1109/ULTSYM.2014.0207
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2014-09-03
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Retina Optical interferometry Laser beams Optical imaging Biomedical imaging Optical surface waves Blood vessels Retinal imaging All-optical photoacoustic microscope optical detection GHz detection bandwidth Brain injury assessment
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in