NDLI: Shear wave elastography method combining phase-sensitive optical coherence tomography and coded acoustic radiation force

Content Provider	IEEE Xplore Digital Library
Author	Thu-Mai Nguyen Shaozhen Song Arnal, B. Wong, E.Y. Wang, R.K. O'Donnell, M.
Copyright Year	2014
Description	Author affiliation: Dept. of Bioeng., Univ. of Washington, Seattle, WA, USA (Thu-Mai Nguyen; Shaozhen Song; Arnal, B.; Wong, E.Y.; Wang, R.K.; O'Donnell, M.)
Abstract	We combined phase-sensitive optical coherence tomography (PhS-OCT) and acoustic radiation force (ARF) to develop a shear wave elastography (SWE) method that could be used for ophthalmic applications. SWE measures tissue stiffness from the speed of shear waves propagating through tissue. Assessing the elastic properties of the cornea and the intraocular lens can, for example, help the management of refractive surgeries (myopia or presbyopia correction). OCT is a non-contact imaging method easily applicable in vivo that provides micron-scale resolution particularly suitable for characterizing ocular tissues. ARF is commonly used to remotely induce shear waves in tissue by emitting short (~100 μs) focused ultrasound pulses. To increase the signal-to-noise ratio (SNR) of detected shear waves, we used a pulse compression method in which the instantaneous peak energy is spread over long (several ms) coded emissions and the detected signal is digitally compressed into a short pulse to increase both SNR and spatio-temporal resolution. The post-compression displacements were used to reconstruct maps of the shear wave speed in gelatin phantoms. We demonstrated the feasibility of using PhS-OCT and ARF to perform elastography at low acoustic pressures (1.5 MPa) owing to the high SNR provided by pulse compression. Future work will focus on implementing this technique for ocular tissues and investigating potential clinical applications.
Starting Page	651
Ending Page	654
File Size	689542
Page Count	4
File Format	PDF
e-ISBN	9781479970490
DOI	10.1109/ULTSYM.2014.0160
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2014-09-03
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Ultrasonic imaging Signal to noise ratio Phantoms Biomedical optical imaging Optical imaging Optical pulse compression intraocular lens shear wave elastography phase-sensitive optical coherence tomography ultrasound radiation force pulse compression amplitude modulation coded excitation cornea
Content Type	Text
Resource Type	Article

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