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Content Provider | IEEE Xplore Digital Library |
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Author | Shu-Wei Liu Yu-Ren Liou Yu-Hsun Wu Ya-Chuen Yang Wang, C.-R.C. Pai-Chi Li |
Copyright Year | 2014 |
Description | Author affiliation: Grad. Inst. of Biomed. Electron. & Bioinf., Nat. Taiwan Univ., Taipei, Taiwan (Shu-Wei Liu; Yu-Ren Liou; Pai-Chi Li) || Dept. of Chem. & Biochem., Nat. Chung-Cheng Univ., Chiayi, Taiwan (Yu-Hsun Wu; Ya-Chuen Yang; Wang, C.-R.C.) |
Abstract | Photothermal therapy is potentially an effective approach to treat cancer. By targeting gold nanorods (AuNRs) to specific tumor sites, laser irradiation can heat the AuNRs and elevate temperature to kill tumor cells. Concentration of AuNRs that can be delivered to tumor cells is the key factor for treatment effects. To enhance delivery, AuNRs encapsulated in perfluorocarbone nanodroplet (AuND) is of particular interest. We hypothesize that by utilizing ultrasound and laser at the same time, AuNDs will undergo liquid-to-gas phase change and the associated cavitational effects will significantly enhance AuNR delivery. To test this hypothesis, in vitro experiments were performed. Results show that the destruction ratio of AuNDs is 45% when both ultrasound and laser are applied. With gold microbubbles (AuMBs) where no liquid-to-gas phase change is present, the destruction ratio is only 35%. Furthermore, the AuNR concentration in the cells is 1.5 times higher for AuNDs than AuMBs. Thus, the combination of laser and ultrasound and the use of AuNDs have the potential to significantly enhance targeted photothermal therapy effects. |
Starting Page | 1666 |
Ending Page | 1669 |
File Size | 289347 |
Page Count | 4 |
File Format | |
e-ISBN | 9781479970490 |
DOI | 10.1109/ULTSYM.2014.0413 |
Language | English |
Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
Publisher Date | 2014-09-03 |
Publisher Place | USA |
Access Restriction | Subscribed |
Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
Subject Keyword | Abstracts Atmospheric measurements Biomedical measurement Particle measurements Lasers |
Content Type | Text |
Resource Type | Article |
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