NDLI: Influence of binding on the vibrational responses of targeted lipid-coated microbubbles

Content Provider	IEEE Xplore Digital Library
Author	van Rooij, T. van der Steen, A.F.W. de Jong, N. Kooiman, K.
Copyright Year	2014
Description	Author affiliation: Dept. of Biomed. Eng., Erasmus MC, Rotterdam, Netherlands (van Rooij, T.; van der Steen, A.F.W.; de Jong, N.; Kooiman, K.)
Abstract	Microbubbles for molecular ultrasound imaging are targeted to disease-specific biomarkers. One of the main challenges is to acoustically distinguish free microbubbles from those that are bound to their molecular target. In this study we used the Brandaris 128 high-speed camera to compare the responses to ultrasound of two types of lipid-coated microbubbles (DSPC and DPPC) in their free and bound state aiming to acoustically discriminate them. We found larger shrinkage for DPPC than for DSPC microbubbles in both their free and bound condition, indicating higher acoustical stability for DSPC-based microbubbles. Upon binding the stability of both types did not change significantly. Frequencies of maximum response were similar for DSPC and DPPC microbubbles, whether they were free or bound. In their free state, more DPPC than DSPC microbubbles responded at the subharmonic and the second harmonic frequency, which did not change upon binding. Interestingly, the maximum relative radial excursions at the second harmonic frequency were higher for DSPC microbubbles when they had bound. In conclusion, bound DSPC and DPPC microbubbles had lower maximum relative radial excursions at the fundamental frequency, and had higher maximum relative radial excursions at the second harmonic frequency than the free microbubbles. We found no differences between bound DSPC and bound DPPC microbubbles. The higher maximum relative radial excursions of particularly bound DSPC microbubbles at the second harmonic frequency may provide opportunities to acoustically discriminate them from free microbubbles.
Starting Page	413
Ending Page	416
File Size	932631
Page Count	4
File Format	PDF
e-ISBN	9781479970490
DOI	10.1109/ULTSYM.2014.0102
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2014-09-03
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Harmonic analysis Ultrasonic imaging Oscillators Acoustics Resonant frequency Cameras nonlinear behavior targeted microbubbles high-speed optical imaging lipid-coating molecular imaging
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Acoustical response of DSPC versus DPPC lipid-coated microbubbles

The Luxembourg-Gorky effect for in vitro characterization of lipid-coated microbubbles

Acoustic characterisation of individual targeted microbubbles with high-frequency ultrasound

Imaging targeted microbubble interactions with microvessels

Segmented high speed imaging of vibrating microbubbles during long ultrasound pulses

The numerical simulation of subharmonic emission from microbubbles

Pressure-dependent resonance frequency for lipid-coated microbubbles at low acoustic pressures

Nonlinear, detection of biodegradable, experimental nanoparticles using a high frequency ultrasound prototype

Nonlinear dynamics of single freely-floating microbubbles under prolonged insonation

Influence of binding on the vibrational responses of targeted lipid-coated microbubbles

Similar Documents

Acoustical response of DSPC versus DPPC lipid-coated microbubbles

The Luxembourg-Gorky effect for in vitro characterization of lipid-coated microbubbles

Acoustic characterisation of individual targeted microbubbles with high-frequency ultrasound

Imaging targeted microbubble interactions with microvessels

Segmented high speed imaging of vibrating microbubbles during long ultrasound pulses

The numerical simulation of subharmonic emission from microbubbles

Pressure-dependent resonance frequency for lipid-coated microbubbles at low acoustic pressures

Nonlinear, detection of biodegradable, experimental nanoparticles using a high frequency ultrasound prototype

Nonlinear dynamics of single freely-floating microbubbles under prolonged insonation

Influence of binding on the vibrational responses of targeted lipid-coated microbubbles