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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Sijia Guo Dingjie Suo Yun Jing Xiaoning Jiang Frank, J. Weili Lin |
| Copyright Year | 2014 |
| Description | Author affiliation: Dept. of Biomed. Eng. & Med. Sch., Univ. of North Carolina at Chapel Hill, Chapel Hill, NC, USA (Frank, J.; Weili Lin) || Dept. of Mech. & Aerosp. Eng., North Carolina State Univ., Raleigh, NC, USA (Sijia Guo; Dingjie Suo; Yun Jing; Xiaoning Jiang) |
| Abstract | It has been demonstrated that high-intensity focused ultrasound can be an efficient method to induce thrombolysis. Excessive thermal effect on neighboring tissue is however a concern. The goal of this work is to test the efficacy of dual-frequency ultrasound-induced thrombolysis, with the aim to reduce the acoustic power required to achieve the same lysis rate (mass loss of blood clots over time) as single-frequency ultrasound. In vitro clots of mouse blood were prepared and placed at the focus of two piezoelectric ultrasound transducers (center frequencies were 0.95 MHz and 1.5 MHz, respectively). 0.65 W ultrasound waves with 10% duty cycle were employed in both single- and dual-frequency ultrasound exposures. The mass losses of the clots were recorded to obtain the lysis rate after each test. It was found that dual-frequency results in more efficient thrombolysis. Cavitation bubble modeling was also conducted for both single- and dual-frequency ultrasound to explain the experimental founding. |
| Starting Page | 2173 |
| Ending Page | 2176 |
| File Size | 880156 |
| Page Count | 4 |
| File Format | |
| e-ISBN | 9781479970490 |
| DOI | 10.1109/ULTSYM.2014.0541 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2014-09-03 |
| Publisher Place | USA |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Ultrasonic imaging Acoustics Mathematical model Transducers Coagulation Equations high-intensity focused ultrasound (HIFU) dual-frequency ultrasound thrombolysis cavitation |
| Content Type | Text |
| Resource Type | Article |
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