NDLI: Diagnostic imaging of molecular-targeted nanorods simultaneously exposed to light and sound

Content Provider	IEEE Xplore Digital Library
Author	McLaughlan, J. Cowell, D. Harput, S. Freear, S.
Copyright Year	2014
Description	Author affiliation: Sch. of Electron. & Electr. Eng., Univ. of Leeds, Leeds, UK (McLaughlan, J.; Cowell, D.; Harput, S.; Freear, S.)
Abstract	Light-absorbing nanorods can be used to improve the signal-to-noise ratio of the thermoelastic emissions from tissue that are used in photoacoustic imaging. As nanorods can be functionalised to selectively target cancer cells, which could then be used to identify and/or destroy them through the formation of ultrasonically driven vapour bubbles. Heating the nanorods with a laser whilst they are simultaneously under tension from a ultrasound field results in a significant reduction in the fluence and pressure thresholds required for bubble formation. A custom build 96-channel diagnostic ultrasound system (4 MHz) was used in conjunction with a nanosecond pulse laser (850 nm) to B-mode image both transparent and turbid tissue-mimicking phantoms, which have been doped with gold nanorods (surface plasmon resonance 850 nm). For a mechanical index of 0.93 (1.86 MPa) and laser fluence of 16 $mJ/cm^{2},$ which are both below safety limits for diagnostic exposures, broadband emissions from the nanorod nucleated vapour bubbles were generated in both phantom types. For the turbid phantom type un-beamformed RF data was filtered using a narrowband filter to remove both the fundamental and second harmonic components of the ultrasound to show only the broadband emissions generated by the inertial collapse of the vapour bubbles. This demonstrates how this technique could be used for the diagnostic imaging of molecular-targeted nanorods.
Starting Page	1626
Ending Page	1629
File Size	11915237
Page Count	4
File Format	PDF
e-ISBN	9781479970490
DOI	10.1109/ULTSYM.2014.0403
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2014-09-03
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Ultrasonic imaging Lasers Phantoms Acoustics Broadband communication Measurement by laser beam
Content Type	Text
Resource Type	Article

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