NDLI: High throughput production of uniformly-sized fluorocarbon emulsions for ultrasonic therapy using a silicon-based microfluidic system

Content Provider	IEEE Xplore Digital Library
Author	Fabiilli, M.L. Silpe, J. Rush, C. Lemmerhirt, D. Tang, E. Vasey, G. Kripfgans, O.D.
Copyright Year	2014
Description	Author affiliation: Dept. of Radiol., Univ. of Michigan Health Syst., Ann Arbor, MI, USA (Fabiilli, M.L.; Silpe, J.; Rush, C.; Lemmerhirt, D.; Tang, E.; Vasey, G.; Kripfgans, O.D.)
Abstract	Sonosensitive particles such as microbubbles and emulsions are typically produced using methods that generate a wide range of particle sizes. These polydisperse distributions are not ideal and thus research efforts have focused on developing techniques to generate more uniformly-sized particles. This works demonstrates the fabrication of a massively parallel microfluidic device consisting of 2,500 channels, which enables fast production rates compared to single channel microfluidic devices. Fluorocarbon emulsions were generated using this device and sized with a Coulter counter. The mean droplet diameters ranged from 5 to 8 μm with coefficients of variance in the range of 14-40%. Production rates as high as 6.5 MHz were observed. Overall, these results indicate that uniformly-sized emulsions can be generated at rates feasible for scale-up.
Starting Page	1770
Ending Page	1773
File Size	2480785
Page Count	4
File Format	PDF
e-ISBN	9781479970490
DOI	10.1109/ULTSYM.2014.0439
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2014-09-03
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Production Microfluidics Junctions Microscopy Acoustics Radiation detectors Silicon ultrasound emulsions contrast agents perfluorocarbon microfluidic uniform-sized
Content Type	Text
Resource Type	Article

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