NDLI: Expiratory flow limitation in mechanically ventilated patients: a simulation study

Content Provider	IEEE Xplore Digital Library
Author	Brighenti, C. Gnudi, G. Cevenini, G. Barbini, P.
Copyright Year	2003
Description	Author affiliation: Dept. of Electron., Bologna Univ., Italy (Brighenti, C.)
Abstract	A non-linear lumped-parameter model of the tracheobronchial tree has been recently proposed to simulate expiratory flow limitation (EFL) in mechanical ventilation. The model is based on Weibel's symmetrical description of lung anatomy subdivided into 24 generations, where the first 17 generations correspond to conductive airways and the last 7 generations belong to the respiratory zone. Thanks to an accurate description of airway viscoelastic properties, the model enables both normal and severe chronic obstructive pulmonary disease (COPD) conditions to be reproduced. In particular, in the present work, normal and COPD cases have been studied and compared during tidal breathing. Presence of EFL in COPD conditions has been detected by means of the "external resistance method," which on the contrary revealed no EFL in normal case. Changes in diameter and resistance of conductive airways have been analyzed giving an increased airways resistance in COPD condition with respect to normal case. Simulation results show as, in patient suffering from COPD, EFL can be ascribed to large modifications in geometry and in elastic characteristics of the conductive airways, combined with a high resistance of lower airways.
Sponsorship	Whitaker Found
Starting Page	411
Ending Page	414
File Size	351288
Page Count	4
File Format	PDF
ISBN	0780377893
ISSN	1094687X
DOI	10.1109/IEMBS.2003.1279692
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2003-09-17
Publisher Place	Mexico
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Immune system Ventilation Lungs Computational modeling Computer science Diseases Artificial intelligence Surgery Biomedical engineering Computer simulation
Content Type	Text
Resource Type	Article

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