NDLI: Three lymphoid-specific factors account for all junctional diversity characteristic of somatic assembly of T-cell receptor and immunoglobulin genes.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1992 Volume: 89 Issue: 24

Year: 1992 Volume: 89 Issue: 23

Year: 1992 Volume: 89 Issue: 22

Year: 1992 Volume: 89 Issue: 21

Year: 1992 Volume: 89 Issue: 20

Year: 1992 Volume: 89 Issue: 19

Year: 1992 Volume: 89 Issue: 18

Year: 1992 Volume: 89 Issue: 17

Year: 1992 Volume: 89 Issue: 16

Year: 1992 Volume: 89 Issue: 15

Year: 1992 Volume: 89 Issue: 14

Year: 1992 Volume: 89 Issue: 13

Year: 1992 Volume: 89 Issue: 12

Year: 1992 Volume: 89 Issue: 11

Year: 1992 Volume: 89 Issue: 10

Year: 1992 Volume: 89 Issue: 9

Year: 1992 Volume: 89 Issue: 8

Year: 1992 Volume: 89 Issue: 7

Synthesis of the early light-inducible protein is controlled by blue light and related to light stress.

Multiple occurrences of mutualism in the yucca moth lineage.

Sequence and expression in Escherichia coli of the 40-kDa subunit of activator 1 (replication factor C) of HeLa cells.

High frequency of single-base transitions and extreme frequency of precise multiple-base reversion mutations in poliovirus.

Chronic deafferentation in monkeys differentially affects nociceptive and nonnociceptive pathways distinguished by specific calcium-binding proteins and down-regulates gamma-aminobutyric acid type A receptors at thalamic levels.

Expression of a cloned rat histamine H2 receptor mediating inhibition of arachidonate release and activation of cAMP accumulation.

Regulation of hepatitis B virus gene expression by its two enhancers.

RAR-beta 4, a retinoic acid receptor isoform is generated from RAR-beta 2 by alternative splicing and usage of a CUG initiator codon.

Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium.

Corticothalamic activation modulates thalamic firing through glutamate 'metabotropic' receptors.

Epinephrine suppresses rap1B.GAP-activated GTPase activity in human platelets.

High-affinity ouabain binding by yeast cells expressing Na+, K(+)-ATPase alpha subunits and the gastric H+, K(+)-ATPase beta subunit.

Plasma membrane inositol 1,4,5-trisphosphate receptor of lymphocytes: selective enrichment in sialic acid and unique binding specificity.

Receptor-specific increase in extracellular matrix production in mouse mesangial cells by advanced glycosylation end products is mediated via platelet-derived growth factor.

Cap-specific mRNA (nucleoside-O2'-)-methyltransferase and poly(A) polymerase stimulatory activities of vaccinia virus are mediated by a single protein.

Structure-function relationship among T-cell receptors specific for lysozyme peptides bound to Ab or Abm-12 molecules.

K-sam gene encodes secreted as well as transmembrane receptor tyrosine kinase.

Interaction of the pertussis toxin peptide containing residues 30-42 with DR1 and the T-cell receptors of 12 human T-cell clones.

On the identity of the major postsynaptic density protein.

Suramin is an inhibitor of DNA topoisomerase II in vitro and in Chinese hamster fibrosarcoma cells.

Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity.

Isolation and sequence analysis of the cDNA for pig kidney fructose 1,6-bisphosphatase.

Uncoupling of the DNA topoisomerase and replication activities of an initiator protein.

Stable growth transformation of human T lymphocytes by herpesvirus saimiri.

Purification, molecular cloning, and functional expression of the cholecystokinin receptor from rat pancreas.

Vesicular stomatitis virus antigenic octapeptide N52-59 is anchored into the groove of the H-2Kb molecule by the side chains of three amino acids and the main-chain atoms of the amino terminus.

Disruption of either the E1 or the E2 regulatory gene of human papillomavirus type 16 increases viral immortalization capacity.

Multiple sulfatase deficiency: catalytically inactive sulfatases are expressed from retrovirally introduced sulfatase cDNAs.

Pituitary hyperplasia induced by ectopic expression of nerve growth factor.

Demonstration of processing and recycling of biologically active V1 vasopressin receptors in vascular smooth muscle.

Hox-1.11 and Hox-4.9 homeobox genes.

Oral antilymphocyte activity and induction of apoptosis by 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine.

Expression of alternatively spliced human T-lymphotropic virus type I pX mRNA in infected cell lines and in primary uncultured cells from patients with adult T-cell leukemia/lymphoma and healthy carriers.

High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis.

The effects of dietary restriction on immune function and development of autoimmune disease in BXSB mice.

Memory cell generation ablated by soluble protein antigen by means of effects on T- and B-lymphocyte compartments.

Serotype conversion in Vibrio cholerae O1.

In vivo T-cell ablation by a holo-immunotoxin directed at human CD3.

Mobilization of dantrolene-sensitive intracellular calcium pools is involved in the cytotoxicity induced by quisqualate and N-methyl-D-aspartate but not by 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionate and kainate in cultured cerebral cortical neurons.

A uridine-rich sequence required for translation of prokaryotic mRNA.

What is the optimum size for the genetic alphabet?

Enhanced expression of the developmentally regulated extracellular matrix molecule tenascin following adult brain injury.

sar: a genetic mouse model for human sarcosinemia generated by ethylnitrosourea mutagenesis.

Infectious Sindbis virus transient expression vectors for studying antigen processing and presentation.

Retinoic acid mimics transforming growth factor beta in the regulation of human immunodeficiency virus expression in monocytic cells.

Reverse transcription polymerase chain reaction for the rearranged retinoic acid receptor alpha clarifies diagnosis and detects minimal residual disease in acute promyelocytic leukemia.

A common antiviral cytotoxic T-lymphocyte epitope for diverse major histocompatibility complex haplotypes: implications for vaccination.

Stimulation of protein-tyrosine phosphorylation in rat striatum after lesion of dopamine neurons or chronic neuroleptic treatment.

Isolation of a candidate human hematopoietic stem-cell population.

CDK2 encodes a 33-kDa cyclin A-associated protein kinase and is expressed before CDC2 in the cell cycle.

p107wee1 is a dual-specificity kinase that phosphorylates p34cdc2 on tyrosine 15.

Both p21ras and pp60v-src are required, but neither alone is sufficient, to activate the Raf-1 kinase.

Molecular associations between the T-lymphocyte antigen receptor complex and the surface antigens CD2, CD4, or CD8 and CD5.

Coordinated synthesis and degradation of cdc2 in the mammalian cell cycle.

Functional characterization of a hybrid human-mouse interferon gamma receptor: evidence for species-specific interaction of the extracellular receptor domain with a putative signal transducer.

Sequence of Prochloron didemni atpBE and the inference of chloroplast origins.

Synergistic suppression: anomalous inhibition of the proliferation of factor-dependent hemopoietic cells by combination of two colony-stimulating factors.

Human cyclin-dependent kinase 2 is activated during the S and G2 phases of the cell cycle and associates with cyclin A.

An 11-base-pair DNA sequence motif apparently unique to the human interleukin 4 gene confers responsiveness to T-cell activation signals.

T-cell responsiveness to an oncogenic peripheral protein and spontaneous autoimmunity in transgenic mice.

A potential splicing factor is encoded by the opposite strand of the trans-spliced c-myb exon.

Probing the energetics of oligo(dT).poly(dA) by laser cross-linking.

Tolerance induction by thymic medullary epithelium.

A lattice model for protein structure prediction at low resolution.

Establishment and characterization of lymphoid and myeloid mixed-cell populations from mouse late embryoid bodies, 'embryonic-stem-cell fetuses'.

Anti-idiotype monoclonal antibody elicits broadly neutralizing anti-gp120 antibodies in monkeys.

Decreased levels of soluble amyloid beta-protein precursor in cerebrospinal fluid of live Alzheimer disease patients.

Genetic structure of forensic populations.

Postsynaptic protein kinase C essential to induction and maintenance of long-term potentiation in the hippocampal CA1 region.

Adenovirus as an expression vector in muscle cells in vivo.

First-order analysis of optical flow in monkey brain.

Expression of a bacterial mtlD gene in transgenic tobacco leads to production and accumulation of mannitol.

Heterogeneous expression of glucokinase among pancreatic beta cells.

Modification of Brassica seed oil by antisense expression of a stearoyl-acyl carrier protein desaturase gene.

Simulations of the folding pathway of triose phosphate isomerase-type alpha/beta barrel proteins.

Nerve growth factor-induced synaptogenesis and hypertrophy of cortical cholinergic terminals.

DNA helical stability accounts for mutational defects in a yeast replication origin.

AlgR2 is an ATP/GTP-dependent protein kinase involved in alginate synthesis by Pseudomonas aeruginosa.

Ligand and DNA-dependent phosphorylation of human progesterone receptor in vitro.

Cloning and physical mapping of the HLA class I region spanning the HLA-E-to-HLA-F interval by using yeast artificial chromosomes.

Interleukin 2 regulates the activity of the lyn protein-tyrosine kinase in a B-cell line.

Murine monoclonal anti-idiotope antibody breaks unresponsiveness and induces a specific antibody response to human melanoma-associated proteoglycan antigen in cynomolgus monkeys.

16S rRNA phylogenetic analysis of the bacterial endosymbionts associated with cytoplasmic incompatibility in insects.

Gene expression in Leishmania: analysis of essential 5' DNA sequences.

Transport and anchoring of beta-lactamase to the external surface of Escherichia coli.

Specific binding of arginine to TAR RNA.

Symmetry conditions for binding processes.

Origin of Gila seminuda (Teleostei: Cyprinidae) through introgressive hybridization: implications for evolution and conservation.

Expression of urinary H-2 odortypes by infant mice.

Mutant p53 can induce tumorigenic conversion of human bronchial epithelial cells and reduce their responsiveness to a negative growth factor, transforming growth factor beta 1.

Partial characterization of vertebrate prothrombin cDNAs: amplification and sequence analysis of the B chain of thrombin from nine different species.

Interleukin (IL)-2 and IL-3 induce distinct but overlapping responses in murine IL-3-dependent 32D cells transduced with human IL-2 receptor beta chain: involvement of tyrosine kinase(s) other than p56lck.

Single-residue changes in class I major histocompatibility complex molecules stimulate responses to self peptides.

Three lymphoid-specific factors account for all junctional diversity characteristic of somatic assembly of T-cell receptor and immunoglobulin genes.

Expression of the mouse tyrosinase gene during embryonic development: recapitulation of the temporal regulation in transgenic mice.

Increased apolipoprotein E and c-fms gene expression without elevated interleukin 1 or 6 mRNA levels indicates selective activation of macrophage functions in advanced human atheroma.

Thymidine-induced mutations in mammalian cells: sequence specificity and implications for mutagenesis in vivo.

Isolation and characterization of a cDNA encoding Drosophila transcription factor TFIIB.

A bipartite DNA binding domain composed of direct repeats in the TATA box binding factor TFIID.

Chlorambucil-induced mutations in mice recovered in homozygotes.

Functional analysis of a type IIB von Willebrand disease missense mutation: increased binding of large von Willebrand factor multimers to platelets.

A protein kinase associated with paired helical filaments in Alzheimer disease.

Photoaffinity labeling of the primary fibrin polymerization site: isolation and characterization of a labeled cyanogen bromide fragment corresponding to gamma-chain residues 337-379.

Photoaffinity labeling of the primary fibrin polymerization site: localization of the label to gamma-chain Tyr-363.

Spectroscopic evidence for conformational relaxation in myoglobin.

Mutual relationships between chromogranins A and B and gastrin in individual gastrin cells.

Beta-globin nonsense mutation: deficient accumulation of mRNA occurs despite normal cytoplasmic stability.

The human cytokine I-309 is a monocyte chemoattractant.

Abnormal secretagogue-induced intracellular free Ca2+ regulation in cystic fibrosis nasal epithelial cells.

Structural alterations of the epidermal growth factor receptor gene in human gliomas.

Synthesis of 5-methylaminomethyl-2-selenouridine in tRNAs: 31P NMR studies show the labile selenium donor synthesized by the selD gene product contains selenium bonded to phosphorus.

Cloning and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to retinaldehyde-binding protein and yeast SEC14p.

Nucleoplasmic localization of prelamin A: implications for prenylation-dependent lamin A assembly into the nuclear lamina.

Analysis of gene expression in single live neurons.

Mouse 5HT1B serotonin receptor: cloning, functional expression, and localization in motor control centers.

DNA damage and mutation in human cells exposed to nitric oxide in vitro.

Role of neuromedin B in control of the release of thyrotropin in hypothyroid and hyperthyroid rats.

Heparin- and sulfatide-binding peptides from the type I repeats of human thrombospondin promote melanoma cell adhesion.

Characterization of the 5' flanking region of the human D1A dopamine receptor gene.

Hormone-induced progesterone receptor phosphorylation consists of sequential DNA-independent and DNA-dependent stages: analysis with zinc finger mutants and the progesterone antagonist ZK98299.

Protein phosphorylation regulates secretion of Alzheimer beta/A4 amyloid precursor protein.

Alteration of a protease-sensitive region of Pseudomonas exotoxin prolongs its survival in the circulation of mice.

Independent domain folding of Pseudomonas exotoxin and single-chain immunotoxins: influence of interdomain connections.

Transactivation and transformation by Myb are negatively regulated by a leucine-zipper structure.

Addition of extra origins of replication to a minichromosome suppresses its mitotic loss in cdc6 and cdc14 mutants of Saccharomyces cerevisiae.

Robustness of the no-interference model for ordering genetic markers.

A 36-base-pair core sequence of locus control region enhances retrovirally transferred human beta-globin gene expression.

Expression, regulation, and chromosomal localization of the Max gene.

A growth-regulated protease activity that is inhibited by the anticarcinogenic Bowman-Birk protease inhibitor.

Developmental and environmental regulation of a mammary gland-specific nuclear factor essential for transcription of the gene encoding beta-casein.

A transcriptional silencer downstream of the promoter in the osmotically controlled proU operon of Salmonella typhimurium.

Induction of heat shock protein closely correlates with protection against Toxoplasma gondii infection.

Year: 1992 Volume: 89 Issue: 6

Year: 1992 Volume: 89 Issue: 5

Year: 1992 Volume: 89 Issue: 4

Year: 1992 Volume: 89 Issue: 3

Year: 1992 Volume: 89 Issue: 2

Year: 1992 Volume: 89 Issue: 1

On the nature of global classification.

Theory of hydrophobicity: transient cavities in molecular liquids.

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Three lymphoid-specific factors account for all junctional diversity characteristic of somatic assembly of T-cell receptor and immunoglobulin genes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kallenbach, S. Fanton D'andon, M. Rougeon, F. Doyen, N.
Description	Author Affiliation: Kallenbach S ( Département d'Immunologie, Institut Pasteur, Paris, France.);
Abstract	The somatic diversity immunoglobulin and T-cell receptor diversity is largely provided by the junctional variation created during site-specific rearrangement of separately encoded gene segments. Using a transient transfection assay, we demonstrate that the recombination activating genes Rag1 and Rag2 direct site-specific rearrangement on an artificial substrate in poorly differentiated as well as in differentiated nonlymphoid cell lines. In addition to a high frequency of precise recombination events, coding joints show deletions and more rarely P-nucleotide insertions, reminiscent of immunoglobulin and T-cell receptor junctions found in fetal tissues. N-region insertions, which are characteristic of adult junctional diversity, are obtained at high frequency upon transfection of a terminal deoxynucleotidyltransferase expression vector together with Rag1 and Rag2. These results show that only three lymphoid-specific factors are needed to generate all types of junctional diversity observed during lymphoid development.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	7
Volume Number	89
Language	English
Publisher	National Academy of Sciences
Publisher Date	1992-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	DNA Nucleotidylexotransferase Genetics DNA-Binding Proteins Gene Rearrangement, B-Lymphocyte Gene Rearrangement, T-Lymphocyte Genes, Immunoglobulin Homeodomain Proteins Proteins Physiology Receptors, Antigen, T-Cell Recombination, Genetic 3T3 Cells Animals Mice Transfection Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in