NDLI: Corticothalamic activation modulates thalamic firing through glutamate 'metabotropic' receptors.

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Corticothalamic activation modulates thalamic firing through glutamate 'metabotropic' receptors.

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Corticothalamic activation modulates thalamic firing through glutamate 'metabotropic' receptors.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Mccormick, D. A. Von Krosigk, M.
Description	Author Affiliation: McCormick DA ( Section of Neurobiology, Yale University School of Medicine, New Haven, CT 06510.);
Abstract	The mammalian thalamus forms an obligatory relay for nearly all sensory information that reaches the cerebral cortex. The transmission of sensory information by the thalamus varies in a state-dependent manner, such that during slow wave sleep or drowsiness thalamic responsiveness is markedly reduced, whereas during the waking, attentive state transmission is enhanced. Although activation of brainstem inputs to thalamic neurons has long been assumed to underlie this gating of sensory transfer through the thalamus, numerically the largest input to thalamic relay neurons derives from layer VI cells of the cerebral cortex. Here we report that activation of corticothalamic fibers causes a prolonged excitatory postsynaptic potential in guinea pig dorsal lateral geniculate relay neurons resulting from the reduction of a potassium conductance, consistent with the activation of glutamatergic 'metabotropic' receptors. This slow depolarization can switch firing of thalamic neurons from the burst firing mode, which is prevalent during slow wave sleep, to the single spike mode, which is prevalent during waking, thereby facilitating transmission of sensory information through the thalamus. This prolonged enhancement of thalamic transfer may allow the cerebral cortex to gate or control selective fields of sensory inputs in a manner that facilitates arousal, attention, and cognition.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	7
Volume Number	89
Language	English
Publisher	National Academy of Sciences
Publisher Date	1992-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cerebral Cortex Physiology Receptors, Neurotransmitter Thalamus Action Potentials Afferent Pathways Animals Electric Conductivity Electric Stimulation Evoked Potentials Geniculate Bodies Guinea Pigs Potassium Potassium Channels Receptors, Glutamate Synaptic Transmission Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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