NDLI: Nerve growth factor-induced synaptogenesis and hypertrophy of cortical cholinergic terminals.

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Nerve growth factor-induced synaptogenesis and hypertrophy of cortical cholinergic terminals.

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Nerve growth factor-induced synaptogenesis and hypertrophy of cortical cholinergic terminals.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Garofalo, L. Ribeiro-da-silva, A. Cuello, A. C.
Description	Author Affiliation: Garofalo L ( Department of Pharmacology, McGill University, Montreal, PQ, Canada.);
Abstract	In this study light and EM quantitative analysis were used to examine whether exogenous nerve growth factor (NGF) could affect terminal fields and synaptic connections in the adult rat brain in vivo. Adult rats received, immediately after unilateral decortication, 2.5S NGF (12 micrograms/day) or vehicle intracerebroventricularly for 7 days. Thirty days after the lesion cholinergic fiber length was quantified, using image analysis, in the remaining cortical area adjacent to the lesion site in each animal. Rats that had received vehicle showed a significantly reduced cortical choline acetyl-transferase-immunoreactive fiber network in the remaining cortex when compared with control animals. By contrast, the network in lesioned rats that had received 2.5S NGF was not different from control animals. Furthermore, the number of cortical choline acetyltransferase-immunoreactive varicosities, which decreased in vehicle-treated lesioned rats, significantly increased above control in lesioned rats that had received 2.5S NGF. At the ultrastructural level, 30 days after the lesion, animals that had received vehicle showed shrunken cholinergic boutons in cortical layer V and fewer synapses compared with control animals. Exogenous NGF, administered to lesioned rats, increased to supernormal levels both size of cholinergic boutons and number of synaptic contacts. These parameters were unaltered in unlesioned rats treated with NGF. This study demonstrates that exogenous NGF can cause significant compensatory changes in terminal fields and synaptic connections in the adult fully differentiated central nervous system.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	7
Volume Number	89
Language	English
Publisher	National Academy of Sciences
Publisher Date	1992-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cerebral Cortex Cytology Cholinergic Fibers Physiology Nerve Growth Factors Pharmacology Synapses Animals Axons Ultrastructure Cell Differentiation Choline O-Acetyltransferase Metabolism Hypertrophy Microscopy, Electron Rats, Inbred Strains Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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