NDLI: Coordinated synthesis and degradation of cdc2 in the mammalian cell cycle.

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Coordinated synthesis and degradation of cdc2 in the mammalian cell cycle.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wang, J. Y. Welch, P. J.
Description	Author Affiliation: Welch PJ ( Department of Biology, University of California, San Diego, La Jolla 92093.);
Abstract	The product of the cdc2 gene (cdc2 or p34cdc2), the catalytic subunit of M phase-promoting factor (MPF), is held at a constant steady-state level throughout the cell cycle. In this report, we show that the constant concentration is maintained by a coordinated regulation of protein synthesis and degradation. At the end of each mitosis, cdc2 transcription is shut off, and the mRNA is rapidly degraded. A 12-fold activation of cdc2 gene transcription occurs every round of the cell cycle at the G1/S transition, in a growth factor-dependent manner. The increase in mRNA correlates with the accumulation of newly synthesized cdc2 during S and G2 phases. At the onset of mitosis, the translation of cdc2 mRNA is shut off. During G1 phase, the cdc2 protein has a relatively long half-life of 18 hr, so cdc2 made in the previous cell cycle is maintained. Once synthesis is activated at G1/S, a concurrent mechanism of degradation is activated, and the protein half-life is reduced to 7.5 hr. By the end of interphase, new cdc2 accounts for 75-85% of the total cdc2 pool. In addition, we show that greater than 75% of the new cdc2 complexes with cyclin, suggesting that a majority of the new cdc2 functions as MPF.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	7
Volume Number	89
Language	English
Publisher	National Academy of Sciences
Publisher Date	1992-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	CDC2 Protein Kinase Metabolism Cell Cycle 3T3 Cells Animals Blotting, Western Genetics Cells, Cultured Cyclins Fibroblasts Gene Expression HeLa Cells In Vitro Techniques Macromolecular Substances Mice Phosphotyrosine RNA, Messenger Transcription, Genetic Tyrosine Analogs & Derivatives Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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