NDLI: Human cyclin-dependent kinase 2 is activated during the S and G2 phases of the cell cycle and associates with cyclin A.

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Human cyclin-dependent kinase 2 is activated during the S and G2 phases of the cell cycle and associates with cyclin A.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Rosenblatt, J. Morgan, D. O. Gu, Y.
Description	Author Affiliation: Rosenblatt J ( Department of Physiology, University of California, San Francisco 94143-0444.);
Abstract	We have analyzed the cell cycle regulation of human cyclin-dependent kinase 2 (CDK2), a protein closely related to the cell cycle-regulatory protein kinase CDC2. We find that CDK2 activity, like that of CDC2, oscillates during the cell cycle in cultured mammalian fibroblasts. Unlike CDC2 activity (which peaks during mitosis), CDK2 activity rises in late G1 or early S phase and declines during mitosis. Active S-phase CDK2 migrates in multiple large complexes on gel filtration, and CDK2 in one of these complexes is associated with cyclin A. These findings suggest that CDK2 and CDC2, in association with distinct cyclins, regulate separate functions in the mammalian cell cycle.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	7
Volume Number	89
Language	English
Publisher	National Academy of Sciences
Publisher Date	1992-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	CDC2-CDC28 Kinases Cell Cycle Cyclin-Dependent Kinases Cyclins Metabolism Protein Kinases Protein-Serine-Threonine Kinases Amino Acid Sequence Cloning, Molecular Cyclin-Dependent Kinase 2 DNA Genetics Enzyme Activation HeLa Cells Macromolecular Substances Molecular Sequence Data Molecular Weight Chemistry Immunology S Phase Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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