NDLI: Mutant p53 can induce tumorigenic conversion of human bronchial epithelial cells and reduce their responsiveness to a negative growth factor, transforming growth factor beta 1.

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Mutant p53 can induce tumorigenic conversion of human bronchial epithelial cells and reduce their responsiveness to a negative growth factor, transforming growth factor beta 1.

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Mutant p53 can induce tumorigenic conversion of human bronchial epithelial cells and reduce their responsiveness to a negative growth factor, transforming growth factor beta 1.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Welsh, J. A. Pfeifer, A. M. Gerwin, B. I. Kispert, J. Forrester, K. Vogelstein, B. Spillare, E. Baker, S. J. Lechner, J. F. Lehman, T. A.
Description	Author Affiliation: Gerwin BI ( Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.);
Abstract	Loss of normal functions and gain of oncogenic functions when the p53 tumor suppressor gene is mutated are considered critical events in the development of the majority of human cancers. Human bronchial epithelial cells (BEAS-2B) provide an in vitro model system to study growth, differentiation, and neoplastic transformation of progenitor cells of lung carcinoma. When wild-type (WT) or mutant (MT; codon 143Val-Ala) human p53 cDNA was transfected into nontumorigenic BEAS-2B cells, we observed that (i) transfected WT p53 suppresses and MT p53 enhances the colony-forming efficiency of these cells, (ii) MT p53 increases resistance to transforming growth factor beta 1, and (iii) clones of MT p53 transfected BEAS-2B cells are tumorigenic when inoculated into athymic nude mice. These results are consistent with the hypothesis that certain mutations in p53 may function in multistage lung carcinogenesis by reducing the responsiveness of bronchial epithelial cells to negative growth factors.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	7
Volume Number	89
Language	English
Publisher	National Academy of Sciences
Publisher Date	1992-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Carcinoma, Bronchogenic Pathology Transforming Growth Factor Beta Pharmacology Tumor Suppressor Protein P53 Genetics Animals Cell Division Drug Effects Genes, P53 In Vitro Techniques Mice Mice, Nude Neoplasm Transplantation Transfection Tumor Cells, Cultured Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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