NDLI: Purification, molecular cloning, and functional expression of the cholecystokinin receptor from rat pancreas.

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Purification, molecular cloning, and functional expression of the cholecystokinin receptor from rat pancreas.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wank, S. A. Jensen, R. T. Shapira, H. De Weerth, A. Harkins, R. Slattery, T.
Description	Author Affiliation: Wank SA ( Digestive Diseases Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892.);
Abstract	The cholecystokinin (CCK) family of peptides and their receptors are widely distributed throughout the gastrointestinal and central nervous systems where they regulate secretion, motility, growth, anxiety, and satiety. The CCK receptors can be subdivided into at least two subtypes, CCKA and CCKB on the basis of pharmacological studies. We report here the purification of the CCKA receptor to homogeneity from rat pancreas by using ion-exchange and multiple affinity chromatographic separations. This allowed partial peptide sequencing after chemical/enzymatic cleavage and synthesis of degenerate oligonucleotide primers. These primers were used for initial cloning of the cDNA from rat pancreas by PCR. The predicted protein sequence of the cDNA clone contained the five partial peptide sequences obtained from the purified protein. Seven putative transmembrane domains suggest its membership in the guanine nucleotide-binding regulatory protein-coupled receptor superfamily. In vitro transcripts of the cDNA clone were functionally expressed in Xenopus oocytes and displayed the expected agonist and antagonist specificity.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	7
Volume Number	89
Language	English
Publisher	National Academy of Sciences
Publisher Date	1992-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Receptors, Cholecystokinin Genetics Amino Acid Sequence Animals Cloning, Molecular Gene Expression Infant, Newborn Molecular Sequence Data Oligodeoxyribonucleotides Chemistry Oocytes Pancreas RNA, Messenger Isolation & Purification Receptors, Neurokinin-3 Receptors, Neurotransmitter Sequence Alignment Xenopus Laevis Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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