NDLI: Recombination sequence-binding protein in thymocytes undergoing T-cell receptor gene rearrangement.

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Recombination sequence-binding protein in thymocytes undergoing T-cell receptor gene rearrangement.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	West, M. Muegge, K. Durum, S. K.
Description	Author Affiliation: Muegge K ( Biological Carcinogenesis and Development Program, Program Resources, Inc.,/Dyncorp, National Cancer Institute-Frederick Cancer Research and Development Center, MD 21702-1201.);
Abstract	Rearrangement of T-cell antigen receptor and immunoglobulin genes occurs in immature lymphoid cells by an unknown mechanism. To identify components of the rearrangement machinery, we isolated a population of murine thymocytes enriched for rearranging pre-T cells. In the nuclear fraction of these cells, we detected a protein that specifically bound the recombination sequences that flank T-cell receptor and immunoglobulin genes and are required for their rearrangement. This protein recognized both heptamer and nonamer motifs of the recombination sequence, separated by either 12 or 23 bp. The protein complexed with the recombination sequence oligonucleotide had an apparent molecular mass of 30 kDa. The binding characteristics of the protein and its presence in rearranging thymocytes and cell lines suggest that it could serve as the recognition unit of a recombinase complex.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	9
Volume Number	90
Language	English
Publisher	National Academy of Sciences
Publisher Date	1993-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Gene Rearrangement, T-Lymphocyte Receptors, Antigen, T-Cell, Alpha-beta Genetics Recombination, Genetic T-Lymphocytes Immunology Animals Cell Line, Transformed Cell Nucleus Metabolism DNA-Binding Proteins Isolation & Purification Radiation Effects Mice Mice, Inbred C57BL Mice, Inbred Strains Molecular Sequence Data Nuclear Proteins Oligodeoxyribonucleotides Radiation Chimera Substrate Specificity T-Lymphocyte Subsets Thymus Gland Time Factors Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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