NDLI: The human cytokine I-309 is a monocyte chemoattractant.

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The human cytokine I-309 is a monocyte chemoattractant.

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The human cytokine I-309 is a monocyte chemoattractant.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Miller, M. D. Krangel, M. S.
Description	Author Affiliation: Miller MD ( Department of Microbiology and Immunology, Duke University Medical Center, Durham, NC 27710.);
Abstract	The human cytokine I-309 is a small glycoprotein secreted by activated T lymphocytes and structurally related to a number of inflammatory cytokines. To investigate the biological activities of I-309 protein, we produced a stable Chinese hamster ovary cell transfectant, CDI.10, which constitutively secretes I-309 protein into culture supernatant. Affinity chromatography on a heparin-Sepharose matrix followed by reverse-phase HPLC was used to purify to homogeneity a glycoprotein doublet of 15-16 kDa from culture supernatant. Biochemical analysis showed the purified recombinant I-309 glycoprotein to be indistinguishable from the natural I-309 glycoprotein constitutively secreted by the T-cell line IDP2. Purified recombinant I-309 stimulated migration of human monocytes but not neutrophils when tested by in vitro chemotaxis assay. Furthermore, the purified protein transiently increased cytoplasmic free calcium concentration in human peripheral blood monocytes but did not do so in lymphocytes or neutrophils. These results demonstrate that the I-309 gene encodes an inflammatory mediator that specifically stimulates human monocytes.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	7
Volume Number	89
Language	English
Publisher	National Academy of Sciences
Publisher Date	1992-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Chemokines, CC Chemotactic Factors Physiology Chemotaxis, Leukocyte Monocytes Amino Acid Sequence Animals CHO Cells Calcium Metabolism Chemokine CCL1 Chemistry Cricetinae Cytoplasm In Vitro Techniques Molecular Sequence Data Neutrophils Recombinant Proteins Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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