NDLI: Regulation of hepatitis B virus gene expression by its two enhancers.

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Regulation of hepatitis B virus gene expression by its two enhancers.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yee, J. K. Su, H.
Description	Author Affiliation: Su H ( Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla 92093-0634.);
Abstract	Hepatitis B virus (HBV) infection causes acute and chronic hepatitis and is closely associated with the development of hepatocellular carcinoma. The principal site of HBV infection is liver, and HBV actively replicates in hepatocytes. Two regions of the HBV genome have been shown previously to display properties of a transcriptional enhancer. In this study, we show that either of the two HBV enhancers can activate all three major HBV promoters in several human hepatoma lines, and the cooperative action of the two enhancers ultimately affects overall activity of the three promoters. In addition, our data suggest that HBV gene expression may be differentially regulated by its enhancers. HBV infection causes chronic liver inflammation and hepatocyte regeneration. It has been proposed that progressive accumulation of mutations during the regenerative hyperplasia may lead to alterations in the differentiation state of hepatocytes. Thus, the development of two differentially regulated enhancers may reflect a strategy of HBV to replicate efficiently in less differentiated hepatocytes during hepatocyte regeneration or hepatocarcinogenesis.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	7
Volume Number	89
Language	English
Publisher	National Academy of Sciences
Publisher Date	1992-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Enhancer Elements, Genetic Gene Expression Regulation, Viral Hepatitis B Virus Genetics Carcinoma, Hepatocellular Microbiology Pathology Cell Differentiation Hepatitis B Core Antigens Hepatitis B Surface Antigens In Vitro Techniques Liver Neoplasms Promoter Regions, Genetic Tumor Cells, Cultured Cytology Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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