NDLI: p107wee1 is a dual-specificity kinase that phosphorylates p34cdc2 on tyrosine 15.

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p107wee1 is a dual-specificity kinase that phosphorylates p34cdc2 on tyrosine 15.

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p107wee1 is a dual-specificity kinase that phosphorylates p34cdc2 on tyrosine 15.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Atherton-fessler, S. Parker, L. L. Piwnica-worms, H.
Description	Author Affiliation: Parker LL ( Department of Physiology, Tufts University School of Medicine, Boston, MA 02111.);
Abstract	p107wee1 is a protein kinase that functions as a dose-dependent inhibitor of mitosis through its interactions with p34cdc2 in Schizosaccharomyces pombe. To characterize the kinase activity of p107wee1, its carboxyl-terminal catalytic domain was purified to homogeneity from overproducing insect cells. The apparent molecular mass of the purified protein (p37wee1KD) was determined to be approximately 37 kDa by gel filtration, consistent with it being a monomer. Serine and tyrosine kinase activities cofiltered with p37wee1KD, demonstrating that p107wee1 is a dual-specificity kinase. In vitro, p107wee1 phosphorylated p34cdc2 on Tyr-15 only when p34cdc2 was complexed with cyclin. Neither monomeric p34cdc2 nor a peptide containing Tyr-15 was able to substitute for the p34cdc2/cyclin complex in this assay. Furthermore, the phosphorylation of p34cdc2 by p107wee1 in vitro inhibited the histone H1 kinase activity of p34cdc2. These results indicate that p107wee1 functions as a mitotic inhibitor by directly phosphorylating p34cdc2 on Tyr-15 and that the preferred substrate for phosphorylation is the p34cdc2/cyclin complex.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	7
Volume Number	89
Language	English
Publisher	National Academy of Sciences
Publisher Date	1992-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	CDC2 Protein Kinase Metabolism Cell Cycle Proteins Nuclear Proteins Protein Kinases Protein-Tyrosine Kinases Antagonists & Inhibitors In Vitro Techniques Phosphorylation Phosphoserine Phosphotyrosine Isolation & Purification Recombinant Proteins Schizosaccharomyces Enzymology Schizosaccharomyces Pombe Proteins Substrate Specificity Tyrosine Analogs & Derivatives Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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