NDLI: Hepatitis B virus X gene can transactivate heterologous viral sequences.

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Hepatitis B virus X gene can transactivate heterologous viral sequences.

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Hepatitis B virus X gene can transactivate heterologous viral sequences.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Robinson, W. S. Twu, J. S.
Description	Author Affiliation: Twu JS ( Division of Infectious Diseases, Stanford University School of Medicine, CA 94305-5107.);
Abstract	The smallest open reading frame of hepatitis B virus (HBV) has been designated the X gene and its biological function during HBV infection and replication is not known. Experiments described here demonstrate that expression of the HBV X gene in HepG2 cells containing a plasmid with the chloramphenicol acetyltransferase (CAT) gene under control of the human immunodeficiency virus (HIV-1) long terminal repeat (LTR) sequence leads to a marked increase in CAT gene transcription as well as expression of the gene product (CAT). The HIV-1 tatIII gene and the HBV X gene together increased HIV-1 LTR-regulated CAT expression above that observed with either gene alone, suggesting a synergistic effect of the X gene and tat. HBV X gene also stimulated expression of the CAT gene under control of the simian virus 40 enhancer and early promoter but not the visna virus LTR or the human T-cell lymphotropic virus type I (HTLV-I) LTR, indicating that the HBV X gene can transactivate some but not other heterologous viral sequences. Transactivation of the HIV-1 LTR by the HBV X gene varied in different cell lines, suggesting that it may be mediated by a cellular factor(s).
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	6
Volume Number	86
Language	English
Publisher	National Academy of Sciences
Publisher Date	1989-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Gene Expression Regulation Genes, Viral Hepatitis B Virus Genetics Cell Line Chloramphenicol O-Acetyltransferase DNA, Recombinant Dexamethasone Pharmacology Enhancer Elements, Genetic Drug Effects HIV Plasmids Promoter Regions, Genetic Repetitive Sequences, Nucleic Acid Simian Virus 40 Species Specificity Transcription, Genetic Transfection Visna-maedi Virus Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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