NDLI: Neovasculature in bone marrow stem cell mobilization for treating myocardial infarction

Content Provider	IEEE Xplore Digital Library
Author	Bin Wang Yao Sun Postlethwaite, A.E. Weber, K.T. Kiani, M.F.
Copyright Year	2002
Description	Author affiliation: Sch. of Biomed. Eng., Univ. of Tennessee Health Sci. Center, Memphis, TN, USA (Bin Wang; Yao Sun; Postlethwaite, A.E.; Weber, K.T.; Kiani, M.F.)
Abstract	Stem cell therapy offers a potential venue with which autologous bone marrow-derived stem cells (BMDSC) have the potential to regenerate functioning myocardial tissue in situ soon after myocardial infarction (MI). When they migrate to sites of MI, they can differentiate into cardiomyocytes, endothelial cells and nerve cells. We have developed a method to substantially increase the small amounts of circulating BMDSC following MI. Rebuilt myocardium must include a vascular network able to nourish it under diverse metabolic demands. We intend to quantify the viability and functionality of the microvasculature 1-4 weeks post MI with or without BMDSC mobilization to assess the ability of this neovasculature to deliver oxygen to the tissue. Fluorescent staining is used to visualize perfused and nonperfused neovasculature, and immunohistochemical staining is used for quantification of tissue hypoxia. Our preliminary results indicate that the decrease in the number of anatomical and perfused vessels after MI, is accompanied by a progressive increase in the distance to the nearest perfused blood vessel and the level of hypoxia in the infarcted tissue. These preclinical studies may aid in design of BMDSC mobilization strategies to treat humans with MI.
Starting Page	748
Ending Page	749
File Size	172037
Page Count	2
File Format	PDF
ISBN	0780376129
ISSN	1094687X
DOI	10.1109/IEMBS.2002.1137051
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2002-10-23
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Bones Stem cells Myocardium Heart Cardiology Visualization Medical treatment Immune system Biochemistry Blood vessels
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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