NDLI: Modeling of feedback interactions between MAP kinase and cAMP signaling pathways

Content Provider	IEEE Xplore Digital Library
Author	Rich, T.C.
Copyright Year	2002
Description	Author affiliation: Dept. of Integrative Biol. & Pharmacology, Texas Univ., Houston, TX, USA (Rich, T.C.)
Abstract	Both the mitogen-activated protein kinase (MAPK) and cAMP signaling pathways play critical roles in cellular responses to external stimuli. Although many molecular interactions between these pathways have been identified, little is known about how such interactions shape the signals transmitted through these pathways. Here I present a theoretical model incorporating known feedback interactions between the MAPK and CAMP signaling pathways. In contrast to previous studies considering only the MAPK cascade, simulations made using this model suggest that, in the presence of feedback regulation from the cAMP signaling pathway, elements of the MAPK cascade do not necessarily behave in a bistable fashion. Rather, under constant stimulus conditions, interactions between these pathways can trigger slow oscillatory responses. Undoubtedly, other feedback interactions not considered here further influence both signaling pathways. Given the large number of interactions between MAPK, cAMP, and other signaling pathways (e.g., Ca/sup 2+/), it seems likely that oscillations in one pathway will trigger oscillations in several others. However, until better in vivo methods are developed for measuring enzyme activity and second messenger concentrations, we will be only be able to consider how information might be encoded within such oscillations.
Starting Page	722
Ending Page	723
File Size	165984
Page Count	2
File Format	PDF
ISBN	0780376129
ISSN	1094687X
DOI	10.1109/IEMBS.2002.1137037
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2002-10-23
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Biochemistry Negative feedback In vivo Biological system modeling Computational biology Proteins Signal processing Amino acids Extracellular Differential equations
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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