NDLI: Dynamics of surface receptor interactions required for an immune response

Content Provider	IEEE Xplore Digital Library
Author	Thomas, V.K. Jianhua Wu Cheng Zhu Dustin, M.L.
Copyright Year	2002
Description	Author affiliation: Program in Molecular Pathogenesis, New York Univ., NY, USA (Thomas, V.K.)
Abstract	We have applied a new method for measuring two dimensional kinetic rates to the study the interactions between receptor important for the regulation of the immune response. The interaction of Cluster of Differentiation (CD) 28 with CD80 stimulates T cell activation, while the interaction of Cytotoxic T Lymphocyte Antigen (CTLA)-4 with CD80 is an antagonist to T cell activation. The new analysis provides information about free ligand diffusion in the contact area, the fraction of interactions that are stable and the kinetic off-rate. Independent data from equilibrium measurements are used to calculate the on-rate. The values for CD28-CD80 interaction reveal a 10-fold reduction in free CD80 diffusion, a small stable fraction of 9.6% and a 2D k/sub r/ of 0.057 s/sup -1/. This compares to an off-rate of 1.6 s/sup -1/ in solution, a difference of 30-fold. The CTLA-4-CD28 system is under analysis, but appears to have slower kinetics, requiring very long recovery time courses for analysis.
Starting Page	345
Ending Page	346
File Size	164525
Page Count	2
File Format	PDF
ISBN	0780376129
ISSN	1094687X
DOI	10.1109/IEMBS.2002.1134527
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2002-10-23
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Kinetic theory Fluorescence Steady-state Equations Photobleaching Immune system Production Area measurement Performance analysis Pathogens
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
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9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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