NDLI: Design and synthesis of novel pH and temperature sensitive copolymers for injectable delivery

Content Provider	IEEE Xplore Digital Library
Author	Mallapragada, S.K. Anderson, B.C.
Copyright Year	2002
Description	Author affiliation: Dept. of Chem. Eng., Iowa State Univ., Ames, IA, USA (Mallapragada, S.K.; Anderson, B.C.)
Abstract	We have developed methods to synthesize a family of novel self-assembling, pH and temperature sensitive water-soluble multiblock copolymers based on poly(ethylene oxide) (PEO) and poly(diethylaminoethylmethacrylate) (PDEAEM) with a variety of nanoarchitectures.. We have developed oxyanionic polymerization techniques to synthesize di-, tri-, and pentablock copolymers of PEO, poly(propylene oxide) (PPO) and PDEAEM, and also random copolymers of poly(ethylene glycol) methyl ether methacrylate and PDEAEM. The pentablock copolymers self-assemble to form nanometer scale micelles in aqueous solutions and above a critical gelation temperature, the micelles entangle and self-assemble to form macroscale thermoreversible water-soluble physical gels. Aqueous solutions of these polymers at room temperatures can be injected into the body where they form physical gels for controlled delivery that eventually dissolve and release the entrapped molecules. They also possess the ability to undergo swelling/syneresis in response to changes in pH. These polymers were characterized by a number of techniques such as NMR, gel permeation chromatography, infrared spectroscopy, etc. Such smart injectable systems could be very useful for insulin in response to glucose changes. These cationic polymers also exhibit complexation with DNA at physiological pH values and are potential as gene therapy vectors.
Starting Page	486
Ending Page	487
File Size	138078
Page Count	2
File Format	PDF
ISBN	0780376129
ISSN	1094687X
DOI	10.1109/IEMBS.2002.1136908
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2002-10-23
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Temperature sensors Self-assembly Polymer gels Temperature control Nuclear magnetic resonance Infrared spectra Insulin Sugar DNA Gene therapy
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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