NDLI: Targeting microparticles to select tissue via radiation induced upregulation of endothelial cell adhesion molecules

Content Provider	IEEE Xplore Digital Library
Author	Haybert, J. Dalal, M.K. Hong Yuan Xin Chen Waleed Gaber, M. Goetz, D.J. Kiani, M.F.
Copyright Year	2002
Description	Author affiliation: Univ. of Tennessee Health Sci. Center, Memphis, TN, USA (Haybert, J.)
Abstract	The up-regulation of certain endothelial cell adhesion molecules in tissue that has been irradiated for therapeutic purposes provides a potential avenue for targeting drugs to select tissue. Microspheres were coated with a mAb to ICAM-1 and the level of adhesion of the anti-ICAM-1 microspheres to irradiated tissue in vitro and in vivo was quantified. Under in vitro flow conditions, the number of adherent microspheres on irradiated human umbilical vein endothelial cells (HUVEC) was 4.5/spl plusmn/0.9 times that of control; this ratio could be enhanced by increasing ligand density on the surface of the microspheres, adding RBC to the suspending media, or reducing shear rate. In vivo in a rat cranial window model, the number of adherent anti-ICAM-1 microspheres in irradiated cerebral tissue was 13 times that of IgG microspheres at 48 hr post-irradiation. In locally irradiated animals, the number of adhering microspheres in unirradiated tissue remained at the basal level.
Starting Page	526
Ending Page	527
File Size	164889
Page Count	2
File Format	PDF
ISBN	0780376129
ISSN	1094687X
DOI	10.1109/IEMBS.2002.1136931
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2002-10-23
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Adhesives In vivo Animals Drugs In vitro Fluorescence Surgery Cranial Humans Ionizing radiation
Content Type	Text
Resource Type	Article

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