NDLI: Modeling stem cell population growth: incorporating parameters for quiescence, differentiation and apoptosis

Content Provider	IEEE Xplore Digital Library
Author	Deasy, B.M. Jankowsi, R.J. Payne, T.R. Greenberger, J.S. Huard, J.
Copyright Year	2002
Description	Author affiliation: Bioeng. Dept., Pittsburgh Univ., PA, USA (Deasy, B.M.; Jankowsi, R.J.; Payne, T.R.)
Abstract	The use of stem cells in cell-mediated therapies or cell transplantation applications will require a controlled, scalable system for expansion of the cells and for control of cellular differentiation. Modeling stem cell population growth is one step towards developing such a system. Stem cell populations are heterogeneous and include cells which are non-mitotic. In particular, stem cells may be quiescent or mitotically active. The mitotically-active cells may 1) self-renew to give rise to similar cells, or 2) divide asymmetrically to give rise to precursor cells (which become may terminally differentiated). Cell populations also may include non-mitotic cells which are apoptotic. Non-exponential growth of the stem cell population is the result of the non-mitotic fraction. In this study, we extend a non-exponential model to incorporate parameters describing the non-dividing population. In particular, the models incorporate terms to account for 1) cell loss due to apoptosis or necrosis and 2) the non-dividing differentiated state of a cell. Murine muscle-derived stem cells (MDSC) will be used to experimentally test the model assumptions and determine the goodness of fit of the models using nonlinear regression. This analysis illustrates the dynamics of proliferation in stem cell populations where cells are undergoing both self-renewal and differentiation.
Starting Page	750
Ending Page	751
File Size	176731
Page Count	2
File Format	PDF
ISBN	0780376129
ISSN	1094687X
DOI	10.1109/IEMBS.2002.1137052
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2002-10-23
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Stem cells Testing Medical control systems Control systems Equations Analysis of variance Pulse measurements Biomedical engineering Laboratories Pediatrics
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

The HomeCare and Circadian rhythm

Effect of hydrostatic pressurization on chondrocyte differentiation

Lab automation in cultivation of adherent cells

In silico estimates of cell electroporation by electrical incapacitation waveforms

Modeling spatial population dynamics of stem cell lineage in tissue growth

Stem Cell Engineering

A testing, evaluating and control system for identifying and stabilizing physiological parameters

Genetic control of quiescence in hematopoietic stem cells

Regulation of hematopoietic stem cells differentiation, self-renewal, and quiescence through the mTOR signaling pathway

Modeling stem cell population growth: incorporating parameters for quiescence, differentiation and apoptosis

Similar Documents

The HomeCare and Circadian rhythm

Effect of hydrostatic pressurization on chondrocyte differentiation

Lab automation in cultivation of adherent cells

In silico estimates of cell electroporation by electrical incapacitation waveforms

Modeling spatial population dynamics of stem cell lineage in tissue growth

Stem Cell Engineering

A testing, evaluating and control system for identifying and stabilizing physiological parameters

Genetic control of quiescence in hematopoietic stem cells

Regulation of hematopoietic stem cells differentiation, self-renewal, and quiescence through the mTOR signaling pathway

Modeling stem cell population growth: incorporating parameters for quiescence, differentiation and apoptosis