NDLI: Influence of vessel geometry on leukocyte adhesion: a Lattice-Boltzmann model

Content Provider	IEEE Xplore Digital Library
Author	Chenghai Sun Migliorini, C. Munn, L.L.
Copyright Year	2002
Description	Author affiliation: Dept. of Radiat. Oncology, Massachusetts Gen. Hosp., Boston, MA, USA (Chenghai Sun; Migliorini, C.; Munn, L.L.)
Abstract	Leukocytes roll and arrest on the vascular endothelium in both normal and pathological immune responses, but the particulate, non-Newtonian nature of blood renders traditional mathematical models of these processes intractable. Here we present a Lattice-Boltzmann approach to quantify the fluid dynamics and forces involved as white blood cells interact with red blood cells in "virtual" blood vessels of various geometries. We report that the normal force imparted by erythrocytes is sufficient to increase leukocyte binding, and that increases in tangential force and torque can promote rolling of previously adherent leukocytes. The ratio of cell diameter to vessel diameter is an important determinant of the form of the interaction. This novel approach can be applied to a large number of biological and industrial problems involving the complex flow of particulate suspensions.
Starting Page	373
Ending Page	374
File Size	175890
Page Count	2
File Format	PDF
ISBN	0780376129
ISSN	1094687X
DOI	10.1109/IEMBS.2002.1136851
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2002-10-23
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Geometry White blood cells Adhesives Solid modeling Atmospheric modeling Pathology Immune system Mathematical model Fluid dynamics Red blood cells
Content Type	Text
Resource Type	Article

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