NDLI: Lutein protects against ischemia/reperfusion injury in rat kidneys.

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Lutein protects against ischemia/reperfusion injury in rat kidneys.

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Lutein protects against ischemia/reperfusion injury in rat kidneys.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Liu, Zhen-Guo Qi, Zong-Cai Liu, Wei-Liang Wang, Wei-Zhi
Description	Author Affiliation: Liu ZG ( Department of Anesthesiology, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China.); Qi ZC ( Department of Anesthesiology, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China.); Liu WL ( Department of Anesthesiology, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China.); Wang WZ ( Department of Anesthesiology, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China.)
Abstract	Ischemiareperfusion (I/R) injury has a major impact on renal dysfunction during transplantation. The present study investigated the role of lutein against I/R injuryinduced oxidative stress in rat kidneys. Biochemical analysis and oxidative stress parameters demonstrated that lutein protected the rat kidney significantly from I/R injury. Pretreatment with lutein significantly increased the total antioxidant capacity with a concomitant decline in the total oxidant status. Rats with I/R injury showed a significant increase in oxidative stress. The results revealed significant increases in the levels of lipid peroxidation and protein carbonyl content with concomitant decreases in enzymic and nonenzymic antioxidants. The activity of these enzymes was reversed and demonstrated a significant increase following lutein pretreatment compared with the rats subjected to I/R injury alone. Furthermore, lutein protected the renal tissue from I/R injury by maintaining normal kidney architecture and led to a reduction in the levels of the renal markers urea and creatinine in the serum. These results demonstrated clear evidence that lutein offered a significant protective effect against I/R injury by enhancing antioxidant defense mechanisms.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	3
Volume Number	11
Language	English
Publisher	Spandidos Publications
Publisher Date	2015-03-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Kidney Diseases Metabolism Lutein Pharmacology Reperfusion Injury Animals Antioxidants Biological Markers Disease Models, Animal Drug Therapy Pathology Kidney Function Tests Lipid Peroxidation Drug Effects Administration & Dosage Oxidants Oxidation-reduction Oxidative Stress Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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