NDLI: When Cri du chat syndrome meets Edwards syndrome.

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Baicalein induces apoptosis of human cervical cancer HeLa cells in vitro.

Differential microRNA expression profile comparison between epidermal stem cells and differentiated keratinocytes.

Treatment with Lingqi capsules suppresses colorectal cancer by inhibiting the hepatocyte growth factor/cMet signal transduction pathway.

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Cyclindependent kinase inhibitor p21 does not impact embryonic endochondral ossification in mice.

Differential expression of microRNAs and their target genes in non-small-cell lung cancer.

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Isolation and characterization of ex vivo expanded mesenchymal stem cells obtained from a surgical patient.

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Twist-related protein 1 enhances oral tongue squamous cell carcinoma cell invasion through ß-catenin signaling.

Antitumor activity of adenoviral vector containing T42 and 4xT42 peptide gene through inducing apoptosis of tumor cells and suppressing angiogenesis.

Increased monocytic CD14â ºHLADRlow/- myeloid-derived suppressor cells in obesity.

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Radiation-induced matrix metalloproteinases limit natural killer cell-mediated anticancer immunity in NCI-H23 lung cancer cells.

Suppression of dendritic cell and T-cell activation by the pRST98 Salmonella plasmid.

When Cri du chat syndrome meets Edwards syndrome.

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Effects of hypothermia combined with neural stem cell transplantation on recovery of neurological function in rats with spinal cord injury.

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Transforming growth factor-ß1 small interfering RNA inhibits growth of human embryonic lung fibroblast HFL-I cells in vitro and defends against radiation-induced lung injury in vivo.

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Resveratrol exerts an anti-apoptotic effect on human bronchial epithelial cells undergoing cigarette smoke exposure.

Association of the paired box 2 gene polymorphism with the susceptibility and pathogenesis of HenochSchönlein purpura in children.

Effects of 5fluorouracil and class III phosphoinositide 3kinase small interfering RNA combination therapy on SGC7901 human gastric cancer cells.

An insight into the key genes and biological functions associated with insulin resistance in adipose tissue with microarray technology.

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Heat shock protein 72 suppresses apoptosis by increasing the stability of X-linked inhibitor of apoptosis protein in renal ischemia/reperfusion injury

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Berberine targets epidermal growth factor receptor signaling to suppress prostate cancer proliferation in vitro.

Glycolysis inhibitor 2-deoxy-D-glucose suppresses carcinogen-induced rat hepatocarcinogenesis by restricting cancer cell metabolism.

Selective colorectal cancer cell lysates enhance the immune function of mature dendritic cells in vitro.

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mRNA expression of glucocorticoid receptor and serological and virological markers of chronic hepatitis B.

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Apigenin inhibits the self-renewal capacity of human ovarian cancer SKOV3derived sphere-forming cells.

Picosecond pulsed electric fields induce apoptosis in a cervical cancer xenograft.

Endoplasmic reticulum stress preconditioning antagonizes low-density lipoprotein-induced inflammation in human mesangial cells through upregulation of XBP1 and suppression of the IRE1 /IKK/NF-κB pathway.

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Cardioprotective effects of tilianin in rat myocardial ischemia-reperfusion injury.

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Domain I-IV of ß2-glycoprotein I inhibits advanced glycation end product-induced angiogenesis by down-regulating vascular endothelial growth factor 2 signaling.

Endoplasmic reticulum stress protects human thyroid carcinoma cell lines against ionizing radiation-induced apoptosis.

Rab25 is responsible for phosphoinositide 3-kinase/AKTmediated cisplatin resistance in human epithelial ovarian cancer cells.

Mouse dead end 1-ß interacts with c-Jun and stimulates activator protein 1 transactivation.

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MicroRNA-451a is associated with cell proliferation, migration and apoptosis in renal cell carcinoma.

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Curcumin-induced histone acetylation inhibition improves stress-induced gastric ulcer disease in rats.

Effect of Melilotus extract on lung injury via the upregulation of tumor necrosis factor- -induced protein-8-like 2 in septic mice.

Impact of losartan and angiotensin II on the expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in rat vascular smooth muscle cells.

Identification of bile biomarkers of biliary tract cancer through a liquid chromatography/mass spectrometry-based metabolomic method.

Bone marrow-derived mesenchymal stem cells protect against lung injury in a mouse model of bronchopulmonary dysplasia.

Effects of sevoflurane on leucine-rich repeat kinase 2-associated Drosophila model of Parkinson's disease.

Expression of B-cell-associated genes in peripheral blood mononuclear cells of patients with symptomatic pulmonary embolism.

Novel oncolytic adenovirus sensitizes renal cell carcinoma cells to radiotherapy via mitochondrial apoptotic cell death.

Reduction of isoproterenol-induced cardiac hypertrophy and modulation of myocardial connexin43 by a KATP channel agonist.

Para-phenylenediamine-induces apoptosis via a pathway dependent on PTK-Ras-Raf-JNK activation but independent of the PI3K/Akt pathway in NRK-52E cells.

Effect of cyclin-dependent kinase 7 silencing on cisplatin sensitivity in endometrial carcinoma cells.

Aberrantly expressed mRNAs and long non-coding RNAs in patients with invasive ductal breast carcinoma: a pilot study.

Conversion of bone marrow mesenchymal stem cells into type II alveolar epithelial cells reduces pulmonary fibrosis by decreasing oxidative stress in rats.

PKM2 gene regulates the behavior of pancreatic cancer cells via mitogen-activated protein kinase pathways.

Lutein protects against ischemia/reperfusion injury in rat kidneys.

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Cyclic stretch induces human bladder smooth muscle cell proliferation in vitro through muscarinic receptors.

Proliferative response of peripheral blood mononuclear cells in anti-Hu antibody-associated patients with paraneoplastic neurological syndrome and their depressant effect on small cell lung cancer cells.

Umbilical cord-derived mesenchymal stem cell therapy for neurological disorders via inhibition of mitogen-activated protein kinase pathway-mediated apoptosis.

Simvastatin induces growth inhibition and apoptosis in HepG2 and Huh7 hepatocellular carcinoma cells via upregulation of Notch1 expression.

Localization and expression of heat shock protein 70 with rat myocardial cell damage induced by heat stress in vitro and in vivo.

Inhibition of poly (ADP-ribose) polymerase and inducible nitric oxide synthase protects against ischemic myocardial damage by reduction of apoptosis.

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Octamer-binding protein 4 affects the cell biology and phenotypic transition of lung cancer cells involving ß-catenin/E-cadherin complex degradation.

Potential roles of the RGMa-FAK-Ras pathway in hippocampal mossy fiber sprouting in the pentylenetetrazole kindling model.

MicroRNA-155 promotes the proliferation and invasion abilities of colon cancer cells by targeting quaking.

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Capsinoids suppress fat accumulation via lipid metabolism.

Regulatory network of differentially expressed genes in metastatic osteosarcoma.

Proteasome inhibitor-induced autophagy in PC12 cells overexpressing A53T mutant α-synuclein

Protective effects of tetrandrine on brain cells in phenobarbital-dependent and -withdrawn rats.

Antitumor and apoptotic activities of the chemical constituents from the ethyl acetate extract of Artemisia indica.

Effect of fibroblast growth factor 9 on the osteogenic differentiation of bone marrow stromal stem cells and dental pulp stem cells.

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When Cri du chat syndrome meets Edwards syndrome.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhou, Yi Sun, Yunxia Xie, Yingjun Chen, Yongzhen Chen, Baojiang Wu, Jianzhu
Description	Author Affiliation: Xie Y ( Department of Prenatal Diagnosis, The First Affiliated Hospital of Sun Yatsen University, Guangzhou, Guangdong 510080, P.R. China.); Zhou Y ( Department of Prenatal Diagnosis, The First Affiliated Hospital of Sun Yatsen University, Guangzhou, Guangdong 510080, P.R. China.); Wu J ( Department of Prenatal Diagnosis, The First Affiliated Hospital of Sun Yatsen University, Guangzhou, Guangdong 510080, P.R. China.); Sun Y ( Department of Neonatology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510080, P.R. China.); Chen Y ( Department of Prenatal Diagnosis, The First Affiliated Hospital of Sun Yatsen University, Guangzhou, Guangdong 510080, P.R. China.); Chen B ( Department of Prenatal Diagnosis, The First Affiliated Hospital of Sun Yatsen University, Guangzhou, Guangdong 510080, P.R. China.)
Abstract	It has been well established that the 5p deletion causes Cri du chat syndrome, typically characterized by a catlike cry, and that duplication of 18q causes Edwards syndrome; the two are rare genetic abnormalities that separately lead to physical and mental impairments. However, the severity of the clinicopathological characteristics that arise when these two aberrations occur in one patient is unknown. Here, the first case in our knowledge of a single patient (a twoyearold female) with 5p partial monosomy and 18q partial trisomy is described. In the present study, chromosome microarray analysis was performed, which identified the imbalance of chromosomes 5 and 18 in the patient. The chromosome aberrations were further confirmed by fluorescence in situ hybridization. By comparing the phenotypes of combined case with those of the individual syndromes, severe clinical phenotypes of the 5p (5p15.33p13.3) deletion were confirmed, however, the net effect of the duplication of 18q22.3q23 was not determined, as this duplication only appeared to have a weak effect on the patient's phenotypes. The correlation between these chromosomal aberrations and their clinical features has implications for the identification of critical regions of 5p and 18q, particularly for the functional mapping of chromosome 18.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	3
Volume Number	11
Language	English
Publisher	Spandidos Publications
Publisher Date	2015-03-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Cri-du-chat Syndrome Diagnosis Genetics Trisomy Child, Preschool Chromosome Aberrations Chromosomes, Human, Pair 18 In Situ Hybridization, Fluorescence Oligonucleotide Array Sequence Analysis Phenotype Syndrome Discipline Molecular Biology
Content Type	Text
Resource Type	Article Case study
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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