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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Demiryilmaz, Ismail Sener, Ebru Cetin, Nihal Altuner, Durdu Akcay, Fatih Suleyman, Halis |
| Description | Author Affiliation: Demiryilmaz I ( Department of General Surgery, Ibni Sina Hospital, Kayseri, Turkey, ismail-2007@hotmail.com.) |
| Abstract | In this study, the biochemical and histopathological effects of thiamine and thiamine pyrophosphate on ischemia-reperfusion induced oxidative damage in rat ovarian tissue were investigated. Animals were divided into four groups of six rat each, ovarian ischemia-reperfusion (IR), 25 mg/kg thiamine + ovarian ischemia-reperfusion (TIR), 25 mg/kg thiamine pyrophosphate + ovarian ischemia-reperfusion (TPIR) and Sham group (SG). The results of the biochemical experiments have shown that the rat ovarian tissue with thiamine treatment, the level of MDA, GSH and the 8-hydroxyguanine are almost the same as the IR group; while in the group with thiamine pyrophosphate treatment, the level of MDA, GSH and the 8-hydroxyguanine are almost the same as the SG. Ovarian tissue of rats in the IR group were congested and dilated vessels, edema, hemorrhage, necrotic and apoptotic cells. In this group, the migration and the adhesion of the polymorphonuclear leucocytes to the endothelium were observed. Both ovaries in TPIR group, there was no difference according to the SG. Histopathology of ovarian tissues in the TIR group was almost the same with the IR group. Our results indicate that thiamine pyrophosphate significantly prevents the ischemia-reperfusion induced oxidative damage in ovarian tissue, whereas thiamine has no effect. In conclusion, we have found that thiamine pyrophosphate prevents oxidative damage due to ischemia-reperfusion injury, whereas thiamine does not have this effect. Furthermore, we have confirmed that the results of our biochemical analyses are in concordance with the histopathological findings. |
| File Format | HTM / HTML |
| ISSN | 02536269 |
| Issue Number | 9 |
| Volume Number | 36 |
| e-ISSN | 19763786 |
| Journal | Archives of Pharmacal Research |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2013-09-01 |
| Publisher Place | Korea (South) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Antioxidants Therapeutic Use Dna Damage Drug Effects Ischemia Drug Therapy Ovary Oxidative Stress Reperfusion Injury Prevention & Control Thiamine Pyrophosphate Animals Administration & Dosage Endothelium, Vascular Immunology Pathology Female Glutathione Metabolism Injections, Intraperitoneal Physiopathology Lipid Peroxidation Malondialdehyde Neutrophil Infiltration Blood Supply Oxidation-reduction Random Allocation Rats Rats, Wistar Etiology Thiamine Comparative Study Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Drug Discovery Molecular Medicine |
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