NDLI: Picosecond pulsed electric fields induce apoptosis in a cervical cancer xenograft.

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Picosecond pulsed electric fields induce apoptosis in a cervical cancer xenograft.

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Picosecond pulsed electric fields induce apoptosis in a cervical cancer xenograft.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Qin, Qin Yao, Chen-Guo Jia, Jia Xiong, Zheng-Ai Zhao, Xiao-Zhen
Description	Author Affiliation: Jia J ( Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, P.R. China.); Xiong ZA ( Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, P.R. China.); Qin Q ( Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, P.R. China.); Yao CG ( State Key Laboratory of Power Transmission Equipment and System Security and New Technology, Chongqing University, Chongqing 400044, P.R. China.); Zhao XZ ( State Key Laboratory of Power Transmission Equipment and System Security and New Technology, Chongqing University, Chongqing 400044, P.R. China.)
Abstract	The aim of the present study was to evaluate the efficacy of picosecond pulsed electric fields (psPEF) on a cervical cancer xenograft. Human cervical cancer xenografts were established in nude mice by transplantation of HeLa cells, and the tumors were then treated with psPEF. The histological changes were observed by hematoxylineosin staining and transmission electron microscopy. The rate of tumor cell apoptosis was determined using a terminal deoxynucleotidyltransferasemediated dUTP nick end labeling assay. The mitochondrial transmembrane potential of the tumor cells was detected by laser scanning confocal microscopy, and the activity of caspase3, 8, 9 and 12 was determined. The inhibitory rate seven days postpsPEF treatment was also calculated. The results showed that exposure to psPEF led to an increased rate of apoptosis, collapse of mitochondrial transmembrane potential, and activation of caspases. The inhibitory rate was 9.11% at day 7. The results of the present study indicate that psPEF may induce apoptosis in a cervical cancer xenograft through the endoplasmic reticulum stress and caspasedependent signaling pathways.
ISSN	17912997
e-ISSN	17913004
DOI	10.3892/mmr.2014.2953
Journal	Molecular Medicine Reports
Issue Number	3
Volume Number	11
Language	English
Publisher	Spandidos Publications
Publisher Date	2015-03-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Antineoplastic Agents Pharmacology Apoptosis Radiation Effects Electroshock Uterine Cervical Neoplasms Metabolism Pathology Animals Administration & Dosage Drug Effects Caspases Cell Line, Tumor Disease Models, Animal Membrane Potential, Mitochondrial Mice Therapy Xenograft Model Antitumor Assays Research Support, Non-u.s. Gov't Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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