NDLI: Effects of mild induced hypothermia on hippocampal connexin 43 and glutamate transporter 1 expression following traumatic brain injury in rats.

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Effects of mild induced hypothermia on hippocampal connexin 43 and glutamate transporter 1 expression following traumatic brain injury in rats.

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Effects of mild induced hypothermia on hippocampal connexin 43 and glutamate transporter 1 expression following traumatic brain injury in rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhou, Hong-Xia Li, Yue-Hong Meng, Ling-Li Zhang, Xiao-Yan Zhang, Chun-Lai
Description	Author Affiliation: Li YH ( Department of Obstetrics and Gynecology, Tangshan Gongren Hospital, Tangshan, Hebei 063000, P.R. China.); Zhang CL ( Department of Cardiology, Tangshan Gongren Hospital, Tangshan, Hebei 063000, P.R. China.); Zhang XY ( School of Basic Medical Sciences, Hebei United University, Tangshan, Hebei 063000, P.R. China.); Zhou HX ( School of Basic Medical Sciences, Hebei United University, Tangshan, Hebei 063000, P.R. China.); Meng LL ( School of Basic Medical Sciences, Hebei United University, Tangshan, Hebei 063000, P.R. China.)
Abstract	Traumatic brain injury (TBI) is a common cause of worldwide disability and mortality. Currently, the incidence and prevalence of TBI is markedly increasing and an effective therapy is lacking. Therapeutic hypothermia (3235Ë C) has been reported to reduce intracranial pressure and induce putative neuroprotective effects. However, the underlying molecular mechanisms remain to be elucidated. The aim of the present study was to investigate the effects of mild induced hypothermia (MIH) on the expression of connexin 43 (Cx43) and glutamate transporter 1 (GLT1) in the hippocampus following TBI in rats. A rat model of TBI was created using a modified weightdrop device, followed by 4 h of hypothermia (33Ë C) or normothermia (37Ë C). A wetdry weight method was used to assess brain edema and spatial learning ability was evaluated using a Morris water maze. The levels of Cx43 and GLT1 were detected by immunohistochemical and western blot analysis, respectively. The results demonstrated that MIH treatment improved TBIinduced brain edema and neurological function deficits. In addition, therapeutic MIH significantly downregulated Cx43 expression and upregulated the levels of GLT1 in the hippocampus postTBI. These findings suggested that treatment with MIH may provide a novel neuroprotective therapeutic strategy for TBI through reversing the increase in Cx43 protein and the decrease in GLT1.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	3
Volume Number	11
Language	English
Publisher	Spandidos Publications
Publisher Date	2015-03-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Brain Injuries Metabolism Connexin 43 Excitatory Amino Acid Transporter 2 Hippocampus Hypothermia, Induced Animals Brain Edema Etiology Pathology Therapy Genetics Disease Models, Animal Gene Expression Immunohistochemistry Maze Learning Memory Up-regulation Research Support, Non-u.s. Gov't Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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