NDLI: Algal sulfated carrageenan inhibits proliferation of MDA-MB-231 cells via apoptosis regulatory genes.

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Algal sulfated carrageenan inhibits proliferation of MDA-MB-231 cells via apoptosis regulatory genes.

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Algal sulfated carrageenan inhibits proliferation of MDA-MB-231 cells via apoptosis regulatory genes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Al-Ktaifani, Mahmoud Abbas, Assef Ghannam, Ahmed Murad, Hossam Hawat, Mohammad
Description	Country affiliation: Syria Author Affiliation: Murad H ( Department of Molecular Biology and Biotechnology, Atomic Energy Commission of Syria, P.O. Box 6091, Damascus, Syria.); Ghannam A ( Department of Molecular Biology and Biotechnology, Atomic Energy Commission of Syria, P.O. Box 6091, Damascus, Syria.); Al-Ktaifani M ( Department of Chemistry, Atomic Energy Commission of Syria, P.O. Box 6091, Damascus, Syria.); Abbas A ( Faculty of Biological Sciences, Tishreen University, P.O. Box 2237, Lattakia, Syria.); Hawat M ( Department of Molecular Biology and Biotechnology, Atomic Energy Commission of Syria, P.O. Box 6091, Damascus, Syria.)
Abstract	Marine algae are prolific sources of sulfated polysaccharides, which may explain the low incidence of certain cancers in countries that traditionally consume marine food. Breast cancer is one of the most common types of nonskin cancer in females. In this study, extracted sulfated carrageenan (ESC), predominantly consisting of Î¹carrageenan extracted from the red alga Laurencia papillosa, was characterized using Fourier transform infrared spectrometry. The biological effects of the identified extract were investigated and its potential cytotoxic activity was tested against the MDAMB231 cancer cell line. The biological biometer of the inhibitory concentration of the polysaccharidetreated MDAMB231 cells was determined as 50 µM. Treatment with 50 µM ESC inhibited cell proliferation and promptly induced cell death through nuclear condensation and DNA fragmentation. Characterization of polysaccharidetreated MDAMB231 cell death revealed that induction of apoptosis occurred via the activation of the extrinsic apoptotic caspase8 gene. The apoptotic signaling pathway was regulated through caspase3, caspase9, p53, Bax and Bcl2 genes. These findings suggest that ESC may serve as a potential therapeutic agent to target breast cancer via prompting apoptosis.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	3
Volume Number	11
Language	English
Publisher	Spandidos Publications
Publisher Date	2015-03-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Apoptosis Drug Effects Genetics Carrageenan Pharmacology Chemistry Caspases Metabolism Cell Line, Tumor Cell Proliferation Dna Fragmentation Dose-response Relationship, Drug Embryonic Stem Cells Gene Expression Research Support, Non-u.s. Gov't Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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