NDLI: MicroRNA let-7a suppresses the growth and invasion of cholesteatoma keratinocytes.

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MicroRNA let-7a suppresses the growth and invasion of cholesteatoma keratinocytes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhang, Wenjing Chen, Xiaohua Qin, Zhaobing
Description	Author Affiliation: Zhang W ( Department of Otology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450003, P.R. China.); Chen X ( Department of Otology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450003, P.R. China.); Qin Z ( Department of Otology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450003, P.R. China.)
Abstract	Cholesteatomas are benign epidermallyderived lesions of the temporal bone that are caused by migration of hyperproliferative keratinocytes into the middle ear and mastoid cavity. The molecular mechanisms that regulate the pathogenesis of cholesteatomas are currently not fully understood. The present study demonstrated the antigrowth and antiinvasive effects of let7a microRNA (miRNA) on cholesteatoma keratinocytes. Let7a inhibited the growth of cholesteatoma keratinocytes through two different mechanisms: Restriction of the proliferation of keratinocytes by promoting cell cycle arrest in the G0/G1 phase, and the induction of apoptosis of the cells. In addition to its role in the inhibition of cell growth, let7a suppressed the migration and invasion of cholesteatoma keratinocytes. A mechanistic study showed that let7a downregulated the expression of miR21. Considering the function of miR21 in the regulation of proliferation and apoptosis, let7a may control cell proliferation and apoptosis by regulating miR21, and its targets, in cholesteatoma keratinocytes. In conclusion, the present study showed that let7a downregulates the expression of miR21, resulting in the suppression of proliferation and induction of apoptosis. The results of the present study reveal the crucial role of let7a miRNA in the inhibition of growth and invasion of cholesteatoma keratinocytes.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	3
Volume Number	11
Language	English
Publisher	Spandidos Publications
Publisher Date	2015-03-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Cholesteatoma Genetics Pathology Keratinocytes Metabolism Micrornas Apoptosis Cell Cycle Cell Line, Tumor Cell Movement Cell Proliferation Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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