NDLI: Propofol alleviates acute lung injury following orthotopic autologous liver transplantation in rats via inhibition of the NADPH oxidase pathway.

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Propofol alleviates acute lung injury following orthotopic autologous liver transplantation in rats via inhibition of the NADPH oxidase pathway.

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Propofol alleviates acute lung injury following orthotopic autologous liver transplantation in rats via inhibition of the NADPH oxidase pathway.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Chi, Xinjin Hei, Ziqing Zhu, Guosong Yao, Weifeng Luo, Gangjian Yuan, Dongdong
Description	Author Affiliation: Luo G ( Department of Anesthesiology, The Third Affiliated Hospital of Sun Yatsen University, Guangzhou, Guangdong 510630, P.R. China.); Zhu G ( Department of Anesthesiology, Henan Provincial People's Hospital, Zhengzhou, Henan 450003, P.R. China.); Yuan D ( Department of Anesthesiology, The Third Affiliated Hospital of Sun Yatsen University, Guangzhou, Guangdong 510630, P.R. China.); Yao W ( Department of Anesthesiology, The Third Affiliated Hospital of Sun Yatsen University, Guangzhou, Guangdong 510630, P.R. China.); Chi X ( Department of Anesthesiology, The Third Affiliated Hospital of Sun Yatsen University, Guangzhou, Guangdong 510630, P.R. China.); Hei Z ( Department of Anesthesiology, The Third Affiliated Hospital of Sun Yatsen University, Guangzhou, Guangdong 510630, P.R. China.)
Abstract	Acute lung injury (ALI) induced by liver transplantation is detrimental to patient survival, and therapeutic strategies remain limited. Thus, the protective effects of propofol, a commonly used anesthetic with antioxidative and antiinflammatory properties, were investigated in the present study on ALI induced by orthotopic autologous liver transplantation (OALT). The protective mechanism of propofol was determined to be associated with the inhibition of NADPH oxidase, by comparing its effects with the positive controls apocynin (AP; an NADPH oxidase inhibitor) and Nacegysteine (NAC; a scavenger of reactive oxygen species). The results demonstrated that two proteins (p47phox and gp91phox) of the NADPH oxidase system presented increased expression in rats with ALI induced by OALT, thus leading to increased activation of the oxidative stress and inflammatory reactions. Preconditioning with NAC or AP eliminated this increase, suggesting that antioxidative treatment, particularly with inhibitors of NADPH oxidase, is a promising protective strategy against ALI induced by OALT. Propofol preconditioning at a high (100 mg/kg) or low (50 mg/kg) dose promoted similar protective effects, with the highdose propofol producing a more marked effect than the low dose. The results suggested that propofol may protect against ALI induced by OALT, the mechanism of which may involve a reduced oxidative stress and inflammatory reaction mediated by NADPH oxidase inhibition.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	3
Volume Number	11
Language	English
Publisher	Spandidos Publications
Publisher Date	2015-03-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Acute Lung Injury Etiology Metabolism Hypnotics And Sedatives Pharmacology Liver Transplantation Adverse Effects Nadph Oxidase Propofol Signal Transduction Drug Effects Drug Therapy Pathology Animals Disease Models, Animal Oxidative Stress Pneumonia Protective Agents Research Support, Non-u.s. Gov't Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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