| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Hu, Guorui Li, Mei Lin, Qian Liu, Zhifeng Jin, Yu Yang, Guang Zhou, Renmin He, Ping |
| Description |
Author Affiliation: He P ( Department of Pediatrics, Medical College of Nanjing University, Nanjing, Jiangsu 210093, P.R. China.); Zhou R ( Department of Pediatrics, Medical College of Nanjing University, Nanjing, Jiangsu 210093, P.R. China.); Hu G ( Department of Pediatrics, Medical College of Nanjing University, Nanjing, Jiangsu 210093, P.R. China.); Liu Z ( Department of Pediatrics, Medical College of Nanjing University, Nanjing, Jiangsu 210093, P.R. China.); Jin Y ( Department of Digestive Disease, Nanjing Children's Hospital, Nanjing Medical University, Nanjing, Jiangsu 210008, P.R. China.); Yang G ( Department of Digestive Disease, Nanjing Children's Hospital, Nanjing Medical University, Nanjing, Jiangsu 210008, P.R. China.); Li M ( Department of Digestive Disease, Nanjing Children's Hospital, Nanjing Medical University, Nanjing, Jiangsu 210008, P.R. China.); Lin Q ( Department of Digestive Disease, Nanjing Children's Hospital, Nanjing Medical University, Nanjing, Jiangsu 210008, P.R. China.) |
| Abstract |
Curcumin is known to possess antiinflammatory properties. Despite the fact that curcumin is known to be a strong inhibitor of H+, K+ATPase activity, the mechanism underlying the curcumininduced inhibition of the transcription of the H+, K+ATPase subunit in gastric mucosal parietal cells remains unclear. The present study investigated the possible mechanism by which curcumin inhibits stomach H+, K+ATPase activity during the acute phase of gastric ulcer disease. A rat model of stressinduced gastric ulcers was produced, in which the antiulcer effects of curcumin were examined. Curcumininduced inhibition of the H+, K+ATPase promoter via histone acetylation, was verified using a chromatin immunoprecipitation assay. The results showed that curcumin improved stressinduced gastric ulcer disease in rats, as demonstrated by increased pH values and reduced gastric mucosal hemorrhage and ulcer index. These effects were accompanied by a significant reduction in the level of histone H3 acetylation at the site of the H+, K+ATPase promoter and in the expression of the gastric H+,K+ATPase subunit gene and protein. In conclusion, curcumin downregulated the acetylation of histone H3 at the site of the H+, K+ATPase promoter gene, thereby inhibiting the transcription and expression of the H+, K+ATPase gene. Curcumin was shown to have a preventive and therapeutic effect in gastric ulcer disease. |
| ISSN |
17912997 |
| e-ISSN |
17913004 |
| Journal |
Molecular Medicine Reports |
| Issue Number |
3 |
| Volume Number |
11 |
| Language |
English |
| Publisher |
Spandidos Publications |
| Publisher Date |
2015-03-01 |
| Publisher Place |
Greece |
| Access Restriction |
Open |
| Subject Keyword |
Anti-inflammatory Agents Pharmacology Curcumin Histones Metabolism Stomach Ulcer Etiology Stress, Physiological Stress, Psychological Acetylation Drug Effects Animals Administration & Dosage Disease Models, Animal Gastric Juice Chemistry Gastric Mucosa Pathology Hydrogen-ion Concentration Promoter Regions, Genetic Rna, Messenger Genetics Sodium-potassium-exchanging Atpase Drug Therapy Research Support, Non-u.s. Gov't Discipline Molecular Biology |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology |
