NDLI: Roles of glucose transporter-1 and the phosphatidylinositol 3kinase/protein kinase B pathway in cancer radioresistance (review).

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Baicalein induces apoptosis of human cervical cancer HeLa cells in vitro.

Differential microRNA expression profile comparison between epidermal stem cells and differentiated keratinocytes.

Treatment with Lingqi capsules suppresses colorectal cancer by inhibiting the hepatocyte growth factor/cMet signal transduction pathway.

Roles of glucose transporter-1 and the phosphatidylinositol 3kinase/protein kinase B pathway in cancer radioresistance (review).

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Differential expression of microRNAs and their target genes in non-small-cell lung cancer.

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Isolation and characterization of ex vivo expanded mesenchymal stem cells obtained from a surgical patient.

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A preliminary study on the role of the complement regulatory protein, cluster of differentiation 55, in mice with diabetic neuropathic pain.

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Twist-related protein 1 enhances oral tongue squamous cell carcinoma cell invasion through ß-catenin signaling.

Antitumor activity of adenoviral vector containing T42 and 4xT42 peptide gene through inducing apoptosis of tumor cells and suppressing angiogenesis.

Increased monocytic CD14â ºHLADRlow/- myeloid-derived suppressor cells in obesity.

Mild clinical manifestation and unusual recovery upon coenzyme Q10 treatment in the first Chinese Leigh syndrome pedigree with mutation m.10197 G>A.

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When Cri du chat syndrome meets Edwards syndrome.

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Annexin A2 knockdown inhibits hepatoma cell growth and sensitizes hepatoma cells to 5-fluorouracil by regulating ß-catenin and cyclin D1 expression.

Transforming growth factor-ß1 small interfering RNA inhibits growth of human embryonic lung fibroblast HFL-I cells in vitro and defends against radiation-induced lung injury in vivo.

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Association of the paired box 2 gene polymorphism with the susceptibility and pathogenesis of HenochSchönlein purpura in children.

Effects of 5fluorouracil and class III phosphoinositide 3kinase small interfering RNA combination therapy on SGC7901 human gastric cancer cells.

An insight into the key genes and biological functions associated with insulin resistance in adipose tissue with microarray technology.

Reversing effect and mechanism of soluble resistance-related calcium-binding protein on multidrug resistance in human lung cancer A549/DDP cells.

Omentin-1 promotes the growth of neural stem cells via activation of Akt signaling.

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Heat shock protein 72 suppresses apoptosis by increasing the stability of X-linked inhibitor of apoptosis protein in renal ischemia/reperfusion injury

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Berberine targets epidermal growth factor receptor signaling to suppress prostate cancer proliferation in vitro.

Glycolysis inhibitor 2-deoxy-D-glucose suppresses carcinogen-induced rat hepatocarcinogenesis by restricting cancer cell metabolism.

Selective colorectal cancer cell lysates enhance the immune function of mature dendritic cells in vitro.

Inhibition of the signal transducer and activator of transcription 3 signaling pathway by Qianliening capsules suppresses the growth and induces the apoptosis of human prostate cells.

mRNA expression of glucocorticoid receptor and serological and virological markers of chronic hepatitis B.

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Expression patterns of dishevelled-2 in different colon tissue segments in Hirschsprung's disease.

Downregulation of c-Met expression does not enhance the sensitivity of gastric cancer cell line MKN-45 to gefitinib.

Overexpression of activated leukocute cell adhesion molecule in gastric cancer is associated with advanced stages and poor prognosis and miR-9 deregulation.

Upregulation of Stat1-HDAC4 confers resistance to etoposide through enhanced multidrug resistance 1 expression in human A549 lung cancer cells.

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Adipose tissue-derived mesenchymal stem cells differentiated into hepatocyte-like cells in vivo and in vitro.

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Apigenin inhibits the self-renewal capacity of human ovarian cancer SKOV3derived sphere-forming cells.

Picosecond pulsed electric fields induce apoptosis in a cervical cancer xenograft.

Endoplasmic reticulum stress preconditioning antagonizes low-density lipoprotein-induced inflammation in human mesangial cells through upregulation of XBP1 and suppression of the IRE1 /IKK/NF-κB pathway.

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Domain I-IV of ß2-glycoprotein I inhibits advanced glycation end product-induced angiogenesis by down-regulating vascular endothelial growth factor 2 signaling.

Endoplasmic reticulum stress protects human thyroid carcinoma cell lines against ionizing radiation-induced apoptosis.

Rab25 is responsible for phosphoinositide 3-kinase/AKTmediated cisplatin resistance in human epithelial ovarian cancer cells.

Mouse dead end 1-ß interacts with c-Jun and stimulates activator protein 1 transactivation.

MicroRNA let-7a suppresses the growth and invasion of cholesteatoma keratinocytes.

MicroRNA-451a is associated with cell proliferation, migration and apoptosis in renal cell carcinoma.

Effects of long-term soft contact lens wear on the corneal thickness and corneal epithelial thickness of myopic subjects.

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Reduced tumorigenicity and drug resistance through the downregulation of octamer-binding protein 4 and Nanog transcriptional factor expression in human breast stem cells.

Curcumin-induced histone acetylation inhibition improves stress-induced gastric ulcer disease in rats.

Effect of Melilotus extract on lung injury via the upregulation of tumor necrosis factor- -induced protein-8-like 2 in septic mice.

Impact of losartan and angiotensin II on the expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in rat vascular smooth muscle cells.

Identification of bile biomarkers of biliary tract cancer through a liquid chromatography/mass spectrometry-based metabolomic method.

Bone marrow-derived mesenchymal stem cells protect against lung injury in a mouse model of bronchopulmonary dysplasia.

Effects of sevoflurane on leucine-rich repeat kinase 2-associated Drosophila model of Parkinson's disease.

Expression of B-cell-associated genes in peripheral blood mononuclear cells of patients with symptomatic pulmonary embolism.

Novel oncolytic adenovirus sensitizes renal cell carcinoma cells to radiotherapy via mitochondrial apoptotic cell death.

Reduction of isoproterenol-induced cardiac hypertrophy and modulation of myocardial connexin43 by a KATP channel agonist.

Para-phenylenediamine-induces apoptosis via a pathway dependent on PTK-Ras-Raf-JNK activation but independent of the PI3K/Akt pathway in NRK-52E cells.

Effect of cyclin-dependent kinase 7 silencing on cisplatin sensitivity in endometrial carcinoma cells.

Aberrantly expressed mRNAs and long non-coding RNAs in patients with invasive ductal breast carcinoma: a pilot study.

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PKM2 gene regulates the behavior of pancreatic cancer cells via mitogen-activated protein kinase pathways.

Lutein protects against ischemia/reperfusion injury in rat kidneys.

Blockade of 11ß-hydroxysteroid dehydrogenase type 1 enzyme inhibits experimental collagenase-induced osteoarthritis.

Cyclic stretch induces human bladder smooth muscle cell proliferation in vitro through muscarinic receptors.

Proliferative response of peripheral blood mononuclear cells in anti-Hu antibody-associated patients with paraneoplastic neurological syndrome and their depressant effect on small cell lung cancer cells.

Umbilical cord-derived mesenchymal stem cell therapy for neurological disorders via inhibition of mitogen-activated protein kinase pathway-mediated apoptosis.

Simvastatin induces growth inhibition and apoptosis in HepG2 and Huh7 hepatocellular carcinoma cells via upregulation of Notch1 expression.

Localization and expression of heat shock protein 70 with rat myocardial cell damage induced by heat stress in vitro and in vivo.

Inhibition of poly (ADP-ribose) polymerase and inducible nitric oxide synthase protects against ischemic myocardial damage by reduction of apoptosis.

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Capsinoids suppress fat accumulation via lipid metabolism.

Regulatory network of differentially expressed genes in metastatic osteosarcoma.

Proteasome inhibitor-induced autophagy in PC12 cells overexpressing A53T mutant α-synuclein

Protective effects of tetrandrine on brain cells in phenobarbital-dependent and -withdrawn rats.

Antitumor and apoptotic activities of the chemical constituents from the ethyl acetate extract of Artemisia indica.

Effect of fibroblast growth factor 9 on the osteogenic differentiation of bone marrow stromal stem cells and dental pulp stem cells.

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Roles of glucose transporter-1 and the phosphatidylinositol 3kinase/protein kinase B pathway in cancer radioresistance (review).

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Fang, Jin Zhou, Shui-Hong Fan, Jun Yan, Sen-Xiang
Description	Author Affiliation: Fang J ( Department of Otolaryngology, The Second Hospital of Jiaxing City, Jiaxing, Zhejiang 314000, P.R. China.); Zhou SH ( Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China.); Fan J ( State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China.); Yan SX ( Department of Radiotherapy, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China.)
Abstract	The mechanisms underlying cancer radioresistance remain unclear. Several studies have found that increased glucose transporter1 (GLUT1) expression is associated with radioresistance. Recently, the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway was reported to be involved in the control of GLUT1 trafficking and activity. Activation of the PI3K/Akt pathway may itself be associated with cancer radioresistance. Thus, increasing attention has been devoted to the effects of modifying the expression of GLUT1 and the PI3K/Akt pathway on the increase in the radiosensitivity of cancer cells. This review discusses the importance of the association between elevated expression of GLUT1 and activation of the PI3K/Akt pathway in the development of radioresistance in cancer.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	3
Volume Number	11
Language	English
Publisher	Spandidos Publications
Publisher Date	2015-03-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Glucose Transporter Type 1 Metabolism Neoplasms Phosphatidylinositol 3-kinases Proto-oncogene Proteins C-akt Radiation Tolerance Signal Transduction Animals Gene Expression Glucose Genetics Anoxia Radiotherapy Protein Binding Research Support, Non-u.s. Gov't Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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