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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Muscella, A. Vetrugno, C. Migoni, D. Biagioni, F. Fanizzi, F. P. Fornai, F. De Pascali, S. A. Marsigliante, S. |
| Description | Country affiliation: Italy Author Affiliation: Muscella A ( Di.S.Te.B.A., University of Salento, Lecce, Italy.); Vetrugno C ( Di.S.Te.B.A., University of Salento, Lecce, Italy.); Migoni D ( Di.S.Te.B.A., University of Salento, Lecce, Italy.); Biagioni F ( I.R.C.C.S. Neuromed, Pozzilli, Italy.); Fanizzi FP ( Di.S.Te.B.A., University of Salento, Lecce, Italy.); Fornai F ( 1] I.R.C.C.S. Neuromed, Pozzilli, Italy [2] Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.); De Pascali SA ( Di.S.Te.B.A., University of Salento, Lecce, Italy.); Marsigliante S ( Di.S.Te.B.A., University of Salento, Lecce, Italy.) |
| Abstract | The higher and selective cytotoxicity of [Pt(O,O'-acac)(γ-acac)(DMS)] toward cancer cell in both immortalized cell lines and in breast cancer cells in primary cultures, stimulated a pre-clinical study so as to evaluate its therapeutic potential in vivo. The efficacy of [Pt(O,O'-acac)(γ-acac)(DMS)] was assessed using a xenograft model of breast cancer developed by injection of MCF-7 cells in the flank of BALB/c nude mice. Treatment of solid tumor-bearing mice with [Pt(O,O'-acac)(γ-acac)(DMS)] induced up to 50% reduction of tumor mass compared with an average 10% inhibition recorded in cisplatin-treated animals. Thus, chemotherapy with [Pt(O,O'-acac)(γ-acac)(DMS)] was much more effective than cisplatin. We also demonstrated enhanced in vivo pharmacokinetics, biodistribution and tolerability of [Pt(O,O'-acac)(γ-acac)(DMS)] when compared with cisplatin administered in Wistar rats. Pharmacokinetics studies with [Pt(O,O'-acac)(γ-acac)(DMS)] revealed prolonged Pt persistence in systemic blood circulation and decreased nefrotoxicity and hepatotoxicity, major target sites of cisplatin toxicity. Overall, [Pt(O,O'-acac)(γ-acac)(DMS)] turned out to be extremely promising in terms of greater in vivo anticancer activity, reduced nephrotoxicity and acute toxicity compared with cisplatin. |
| File Format | HTM / HTML |
| e-ISSN | 20414889 |
| DOI | 10.1038/cddis.2013.554 |
| Journal | Cell Death and Disease |
| Volume Number | 5 |
| Language | English |
| Publisher | Nature Publishing Group |
| Publisher Date | 2014-01-23 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Research Support, Non-u.s. Gov't Rats, Wistar Organoplatinum Compounds Mice, Inbred Balb C Breast Neoplasms Drug Evaluation, Preclinical Disease Models, Animal Adverse Effects Drug Therapy Antineoplastic Agents Administration & Dosage Drug Effects Xenograft Model Antitumor Assays Discipline Cell Biology Animals Mice, Nude Cell Line, Tumor Mice Pharmacokinetics Apoptosis |
| Content Type | Text |
| Resource Type | Article |
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